1'-benzyl-5-(cyclopropylmethyl)-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine]

Base Information

Chemical Name:1'-benzyl-5-(cyclopropylmethyl)-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine]
CAS No.:1298034-60-2
Molecular Formula:C₂₄H₃₀N₂O
Molecular Weight:362.515
Hs Code.:

Synonyms:1'-benzyl-5-(cyclopropylmethyl)-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine]

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1'-benzyl-5-(cyclopropylmethyl)-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine]

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Technology Process of 1'-benzyl-5-(cyclopropylmethyl)-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine]

There total 5 articles about 1'-benzyl-5-(cyclopropylmethyl)-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 7051-34-5
cyclopropylcarbinyl bromide

: 693789-32-1
1'-benzyl-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine]

: 1298034-60-2
1'-benzyl-5-(cyclopropylmethyl)-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine]

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 20h;
DOI:10.1016/j.ejmech.2011.02.002

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 1298034-60-2
1'-benzyl-5-(cyclopropylmethyl)-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine]

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyrrolidine / ethanol / Reflux

2.1: pyridine; hydroxylamine hydrochloride / ethanol / 22 h / 0 - 70 °C

3.1: diisobutylaluminium hydride / dichloromethane / 4 h / 0 °C

3.2: 0.33 h / 0 °C

3.3: 0 °C / pH > 9

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 50 °C

With pyrrolidine; pyridine; hydroxylamine hydrochloride; diisobutylaluminium hydride; potassium carbonate; In ethanol; dichloromethane; N,N-dimethyl-formamide; 3.1: Beckmann rearrangement / 3.2: Beckmann rearrangement / 3.3: Beckmann rearrangement;
DOI:10.1016/j.ejmech.2011.02.002

Reference yield:

: 693789-31-0
1'-benzylspiro[chromene-2,4'-piperidin]-4(3H)-one oxime

: 1298034-60-2
1'-benzyl-5-(cyclopropylmethyl)-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine]

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / dichloromethane / 4 h / 0 °C

1.2: 0.33 h / 0 °C

1.3: 0 °C / pH > 9

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 50 °C

With diisobutylaluminium hydride; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; 1.1: Beckmann rearrangement / 1.2: Beckmann rearrangement / 1.3: Beckmann rearrangement;
DOI:10.1016/j.ejmech.2011.02.002