693789-31-0Relevant academic research and scientific papers
Synthesis and structural studies of a novel scaffold for drug discovery: A 4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4′-piperidine]
Willand, Nicolas,Beghyn, Terence,Nowogrocki, Guy,Gesquiere, Jean-Claude,Deprez, Benoit
, p. 1051 - 1054 (2004)
We describe the three-step synthesis of a novel 4,5-dihydro-3H-spiro[1,5- benzoxazepine-2,4′-piperidine] scaffold from ortho-hydroxyacetophenone and N-benzylpiperidone. The structure of one disubstituted derivative, studied by NOESY NMR in an aqueous medi
Discovery of novel SCD1 inhibitors: 5-Alkyl-4,5-dihydro-3H-spiro[1,5- benzoxazepine-2,4′-piperidine] analogs
Uto, Yoshikazu,Ueno, Yuko,Kiyotsuka, Yohei,Miyazawa, Yuriko,Kurata, Hitoshi,Ogata, Tsuneaki,Takagi, Toshiyuki,Wakimoto, Satoko,Ohsumi, Jun
, p. 1892 - 1896 (2011/04/27)
Expansion of the 6-membered ring and subsequent fine-tuning of the newly obtained 7-membered spiropiperidine structure resulted in the discovery of a series of novel and potent SCD1 inhibitors. Preliminary SAR was explored by modifying an alkyl chain on t
BENZO-FUSED OXAZEPINE COMPOUNDS AS STEAROYL-COENZYME A DELTA-9 DESATURASE INHIBITORS
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Page/Page column 46, (2011/02/24)
The present invention relates to certain 4,5-dihydro-3H-spiro[benzo[b]-[1,4]oxazepine compounds of the Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, m, n, o, a
A library of novel hydroxamic acids targeting the metallo-protease family: Design, parallel synthesis and screening
Flipo, Marion,Beghyn, Terence,Charton, Julie,Leroux, Virginie A.,Deprez, Benoit P.,Deprez-Poulain, Rebecca F.
, p. 63 - 76 (2007/10/03)
We report here the design and parallel synthesis of 217 compounds based on a malonic-hydroxamic acid template. These compounds are obtained via a two-step solution-phase procedure. The set of diverse building-blocks used makes this strategy suitable for t
Synthesis of new substituted 4,5-dihydro-3H-spiro[1,5]-benzoxazepine-2, 4′-piperidine and biological properties
Laras, Younes,Pietrancosta, Nicolas,Moret, Vincent,Marc, Sylvain,Garino, Cedrik,Rolland, Amandine,Monnier, Valerie,Kraus, Jean-Louis
, p. 812 - 818 (2007/10/03)
The reduction of substituted spiro-piperidinyl chromanone oximes with DIBAH reagents has been known to afford the corresponding substituted 4,5-dihydro-3H-spiro[1,5]-benzoxazepine-2,4?-piperidine. The position and electronic effects of the substituents on
