Technology Process of 1-methyl-3-phenylperhydro-1,2-diazocine
There total 6 articles about 1-methyl-3-phenylperhydro-1,2-diazocine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium aluminium tetrahydride;
In
1,4-dioxane;
for 19h;
Heating;
DOI:10.1021/jo01313a043
- Guidance literature:
-
With
potassium tert-butylate; tert-butyl alcohol;
In
ethyl acetate;
at 85 - 90 ℃;
for 42h;
Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1021/jo00324a047
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 88.5 percent / glacial acetic acid, hydrochlorid acid, NaNO2 / H2O / 1.) 0 deg C, 6 h, 2.) room temp., 12 h
2: 22.0 g / LiAlH4 / diethyl ether / 16.5 h / Heating
3: 3.55 g / acetonitrile / 17 h / Heating
4: t-BuOK, t-BuOH / ethyl acetate / 42 h / 85 - 90 °C
With
hydrogenchloride; lithium aluminium tetrahydride; potassium tert-butylate; acetic acid; tert-butyl alcohol; sodium nitrite;
In
diethyl ether; water; ethyl acetate; acetonitrile;
DOI:10.1021/jo00324a047
