2,2-dimethyl-1-(4-trifluoromethyl-phenylcarbamoyl)-cyclopropanecarboxylic acid ethyl ester

Base Information

• Chemical Name: 2,2-dimethyl-1-(4-trifluoromethyl-phenylcarbamoyl)-cyclopropanecarboxylic acid ethyl ester
• CAS No.: 885454-68-2
• Molecular Formula: C₁₆H₁₈F₃NO₃
• Molecular Weight: 329.319
• Mol file: 885454-68-2.mol

Synonyms:2,2-dimethyl-1-(4-trifluoromethyl-phenylcarbamoyl)-cyclopropanecarboxylic acid ethyl ester

Chemical Property of 2,2-dimethyl-1-(4-trifluoromethyl-phenylcarbamoyl)-cyclopropanecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2,2-dimethyl-1-(4-trifluoromethyl-phenylcarbamoyl)-cyclopropanecarboxylic acid ethyl ester

There total 2 articles about 2,2-dimethyl-1-(4-trifluoromethyl-phenylcarbamoyl)-cyclopropanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

ethyl 1-(chlorocarbonyl)-2,2dimethylcyclopropanecarboxylate (885454-62-6) + 4-trifluoromethylphenylamine (455-14-1) → 2,2-dimethyl-1-(4-trifluoromethyl-phenylcarbamoyl)-cyclopropanecarboxylic acid ethyl ester (885454-68-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 1.5h;

DOI:10.1080/00397910500446530

Reference yield:

diethyl 2,2-dimethyl cyclopropane 1,1-dicarboxylate (16783-05-4) → 2,2-dimethyl-1-(4-trifluoromethyl-phenylcarbamoyl)-cyclopropanecarboxylic acid ethyl ester (885454-68-2)

Guidance literature:

Multi-step reaction with 3 steps

1: NaOH; ethanol / 12 h / 20 °C

2: thionyl chloride / petroleum ether / Heating

3: 65 percent / triethylamine / tetrahydrofuran / 1.5 h / 0 - 20 °C

With sodium hydroxide; thionyl chloride; ethanol; triethylamine; In tetrahydrofuran; Petroleum ether;

DOI:10.1080/00397910500446530

Reference yield:

2,2-dimethyl-1-(4-trifluoromethyl-phenylcarbamoyl)-cyclopropanecarboxylic acid ethyl ester (885454-68-2) → 2,2-dimethyl-1-(4-trifluoromethyl-phenylcarbamoyl)-cyclopropanecarboxylic acid (885454-73-9)

Guidance literature:

With methanol; sodium hydroxide; for 2h; Heating;

DOI:10.1080/00397910500446530

upstream raw materials:

ethyl 1-(chlorocarbonyl)-2,2dimethylcyclopropanecarboxylate

4-trifluoromethylphenylamine

diethyl 2,2-dimethyl cyclopropane 1,1-dicarboxylate

Downstream raw materials:

2,2-dimethyl-1-(4-trifluoromethyl-phenylcarbamoyl)-cyclopropanecarboxylic acid