(2R,4R)-N-tert-butoxycarbonyl-4-[3-benzoyl-5-iodouracil-1-yl]proline diphenylmethyl ester

Base Information

Chemical Name:(2R,4R)-N-tert-butoxycarbonyl-4-[3-benzoyl-5-iodouracil-1-yl]proline diphenylmethyl ester
CAS No.:1352327-61-7
Molecular Formula:C₃₄H₃₂IN₃O₇
Molecular Weight:721.548
Hs Code.:

Synonyms:(2R,4R)-N-tert-butoxycarbonyl-4-[3-benzoyl-5-iodouracil-1-yl]proline diphenylmethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,4R)-N-tert-butoxycarbonyl-4-[3-benzoyl-5-iodouracil-1-yl]proline diphenylmethyl ester

Chemical Property:

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Technology Process of (2R,4R)-N-tert-butoxycarbonyl-4-[3-benzoyl-5-iodouracil-1-yl]proline diphenylmethyl ester

There total 1 articles about (2R,4R)-N-tert-butoxycarbonyl-4-[3-benzoyl-5-iodouracil-1-yl]proline diphenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 161263-60-1
5-iodo-3-benzoyl-1,3-dihydropyrimidine-2,4-dione

: 189163-47-1
N-tert-butoxycarbonyl-trans-4-hydroxy-D-proline diphenylmethyl ester

: 1352327-61-7
(2R,4R)-N-tert-butoxycarbonyl-4-[3-benzoyl-5-iodouracil-1-yl]proline diphenylmethyl ester

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 24.25h; Inert atmosphere;
DOI:10.1002/asia.201100490

Reference yield:

: 1352327-61-7
(2R,4R)-N-tert-butoxycarbonyl-4-[3-benzoyl-5-iodouracil-1-yl]proline diphenylmethyl ester

: 164461-18-1
1-pyrenylboronic acid

: 1352327-62-8
(2R,4R)-N-tert-butoxycarbonyl-4-[3-benzoyl-5-(pyren-1-yl)uracil-1-yl]proline diphenylmethyl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In acetonitrile; at 80 ℃; for 40h; Inert atmosphere;
DOI:10.1002/asia.201100490

Reference yield:

: 1352327-61-7
(2R,4R)-N-tert-butoxycarbonyl-4-[3-benzoyl-5-iodouracil-1-yl]proline diphenylmethyl ester

: 1352327-63-9
(2R,4R)-N-tert-butoxycarbonyl-4-[5-(pyren-1-yl)uracil-1-yl]proline diphenylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / acetonitrile / 40 h / 80 °C / Inert atmosphere

2: ethanolamine / N,N-dimethyl-formamide / 0.33 h

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ethanolamine; triethylamine; In N,N-dimethyl-formamide; acetonitrile; 1: Suzuki-Miyaura coupling;
DOI:10.1002/asia.201100490