161263-60-1

Basic information

• Product Name: 2,4(1H,3H)-Pyrimidinedione, 3-benzoyl-5-iodo-
• Synonyms: 5-iodo-3-benzoyl-1,3-dihydropyrimidine-2,4-dione;N3-benzoyl-5-iodouracil;2,4(1H,3H)-Pyrimidinedione,3-benzoyl-5-iodo;3-N-benzoyl-5-iodouracil
• CAS NO: 161263-60-1
• Molecular Formula: C11H7IN2O3
• Molecular Weight: 342.093
• Mol File: 161263-60-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 203-205 °C
• Density: 1.98±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 2,4(1H,3H)-Pyrimidinedione, 3-benzoyl-5-iodo-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4(1H,3H)-Pyrimidinedione, 3-benzoyl-5-iodo-(161263-60-1)
• EPA Substance Registry System: 2,4(1H,3H)-Pyrimidinedione, 3-benzoyl-5-iodo-(161263-60-1)

Safety Data

• Hazardous Substances Data: 161263-60-1(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 2775-87-3 3-N-benzoyluracil 
• 696-07-1 5-iodouracil 

Downstream Products

• 149312-08-3 1-(hexahydro-2-phenylpyrano[3,2-d][1,3]dioxin-7-yl)-5-iodopyrimidine-2,4-(1H,3H)-dione 
• 865838-18-2 (3R,4S,6aR)-3-benzoyl-1-(5-fluoro-2,2-dimethyl-6-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl)-5-iodo-1H-pyrimidine-2,4-dione 
• 1352327-61-7 (2R,4R)-N-tert-butoxycarbonyl-4-[3-benzoyl-5-iodouracil-1-yl]proline diphenylmethyl ester 
• 1352327-62-8 (2R,4R)-N-tert-butoxycarbonyl-4-[3-benzoyl-5-(pyren-1-yl)uracil-1-yl]proline diphenylmethyl ester 

Relevant articles and documents

Discovery of New Acid Ceramidase-Targeted Acyclic 5-Alkynyl and 5-Heteroaryl Uracil Nucleosides

A series of novel N-acyclic uracil analogs with linear, branched, aromatic, and cyclopropyl-alkynyl as well as heteroaryl moieties at C-5 were prepared using palladium catalyzed Sonogashira and Stille cross-coupling and evaluated against malignant tumor cell lines. C-5-Furan-2-yl uracil derivative 6 was shown to be more potent against MCF-7 than the reference drug 5-fluorouracil (5-FU), while C-5-alkynyl uracil derivatives 9c and 9e exhibited antibreast cancer activities comparable to 5-FU. Selected compounds induced cell death, partially due to apoptosis, of MCF-7 breast cancer cells. Abrogation of acid ceramidase (ASAH1) expression of 9c and 9e indicated that these compounds could perturb ASAH1-mediated sphingolipid signaling. The selective activity of 9c and 9e against breast cancer cells via the ASAH1-mediated signaling, as a molecular target, might have a great advantage for potential future therapeutic use.

Expeditious convergent procedure for the preparation of bis(POC) prodrugs of new (E)-4-phosphono-but-2-en-1-yl nucleosides

A series of unsaturated acyclonucleoside bis(POC) prodrugs of E configuration were synthesized through an expeditious, highly efficient and stereoselective one-step procedure from corresponding bis(POC)allylphosphonate through Ru catalyzed cross-coupling metathesis reaction. The [RuCl 2(PCy3)(SIPr)(Indenylidene)] and [RuCl 2(PCy3)(IMes)(benzylidene)] catalysts were employed; the unsaturated ANP were used bore C5-halovinyl uracil, C5-dihalovinyluracil or furanopyrimidine motifs. The chemical cleavage of biolabile (POC) group is a useful pathway to acid phosphonate derivatives.

AZABICYCLO [3. 1. 0] HEXYL DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS

The present invention relates to novel compounds of formula (I)' or a salt thereof: wherein G is selected from a group consisting of: phenyl, a 5- or 6-membered monocyclic heteroaryl group, or a 8- to 11 -membered heteroaryl bicyclic group; A is a group P