((2R,6S)-6-Benzyloxymethyl-tetrahydro-pyran-2-yl)-acetaldehyde

Base Information

• Chemical Name: ((2R,6S)-6-Benzyloxymethyl-tetrahydro-pyran-2-yl)-acetaldehyde
• CAS No.: 863660-01-9
• Molecular Formula: C₁₅H₂₀O₃
• Molecular Weight: 248.322
• Mol file: 863660-01-9.mol

Synonyms:((2R,6S)-6-Benzyloxymethyl-tetrahydro-pyran-2-yl)-acetaldehyde

Chemical Property of ((2R,6S)-6-Benzyloxymethyl-tetrahydro-pyran-2-yl)-acetaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of ((2R,6S)-6-Benzyloxymethyl-tetrahydro-pyran-2-yl)-acetaldehyde

There total 1 articles about ((2R,6S)-6-Benzyloxymethyl-tetrahydro-pyran-2-yl)-acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(-)-2-((2R,6S)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-yl)ethanol (863662-92-4) → ((2R,6S)-6-Benzyloxymethyl-tetrahydro-pyran-2-yl)-acetaldehyde (863660-01-9)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/ol8011474

Reference yield: 98.0%

carbon tetrabromide (558-13-4) + ((2R,6S)-6-Benzyloxymethyl-tetrahydro-pyran-2-yl)-acetaldehyde (863660-01-9) → (2S,6R)-2-Benzyloxymethyl-6-(3,3-dibromo-allyl)-tetrahydro-pyran (863662-93-5)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1021/jo0507993

Reference yield: 90.0%

pinacol dichloromethylboronic ester (83622-41-7) + ((2R,6S)-6-Benzyloxymethyl-tetrahydro-pyran-2-yl)-acetaldehyde (863660-01-9) → C22H33BO4

Guidance literature:

With chromium dichloride; lithium iodide; In tetrahydrofuran; Inert atmosphere;

DOI:10.1021/ol8011474

upstream raw materials:

(-)-2-((2R,6S)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-yl)ethanol

Downstream raw materials:

(2S,6R)-2-Benzyloxymethyl-6-(3,3-dibromo-allyl)-tetrahydro-pyran

(2S,6R)-2-Benzyloxymethyl-6-prop-2-ynyl-tetrahydro-pyran

5-[(E)-3-((2R,6S)-6-Benzyloxymethyl-tetrahydro-pyran-2-yl)-propenyl]-2,2-dimethyl-benzo[1,3]dioxin-4-one

2-Hydroxy-6-[3-((2S,6S)-6-vinyl-tetrahydro-pyran-2-yl)-propyl]-benzoic acid (1R,2S)-1-((S)-2-benzyloxy-3-{(2S,6R)-6-[1-methyl-1-(2-trimethylsilanyl-ethoxycarbonyl)-ethyl]-tetrahydro-pyran-2-yl}-propyl)-2-methyl-but-3-enyl ester