rac-2-tert-butoxycarbonylamino-3-(2-fluoro-5-iodo-phenyl)-propionic acid

Base Information

Chemical Name:rac-2-tert-butoxycarbonylamino-3-(2-fluoro-5-iodo-phenyl)-propionic acid
CAS No.:1259957-70-4
Molecular Formula:C₁₄H₁₇FINO₄
Molecular Weight:409.196
Hs Code.:

Synonyms:rac-2-tert-butoxycarbonylamino-3-(2-fluoro-5-iodo-phenyl)-propionic acid

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Chemical Property of rac-2-tert-butoxycarbonylamino-3-(2-fluoro-5-iodo-phenyl)-propionic acid

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Technology Process of rac-2-tert-butoxycarbonylamino-3-(2-fluoro-5-iodo-phenyl)-propionic acid

There total 4 articles about rac-2-tert-butoxycarbonylamino-3-(2-fluoro-5-iodo-phenyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1435479-71-2
2-tert-butoxycarbonylamino-2-(2-fluoro-5-iodo-benzyl)-malonic acid diethyl ester

: 1259957-70-4
rac-2-tert-butoxycarbonylamino-3-(2-fluoro-5-iodo-phenyl)-propionic acid

Guidance literature:: With water; sodium hydroxide; In ethanol; at 40 - 100 ℃; for 16h;

Reference yield:

: 438050-27-2
(2-fluoro-5-iodo-phenyl)-methanol

: 1259957-70-4
rac-2-tert-butoxycarbonylamino-3-(2-fluoro-5-iodo-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: phosphorus tribromide / dichloromethane / 1 h / 0 °C

2: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere

3: sodium hydroxide; water / ethanol / 16 h / 40 - 100 °C

With water; phosphorus tribromide; sodium hydride; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 124700-41-0
2-fluoro-5-iodobenzoic acid

: 1259957-70-4
rac-2-tert-butoxycarbonylamino-3-(2-fluoro-5-iodo-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: borane-THF / tetrahydrofuran / 2 h / 0 - 70 °C / Inert atmosphere

2: phosphorus tribromide / dichloromethane / 1 h / 0 °C

3: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere

4: sodium hydroxide; water / ethanol / 16 h / 40 - 100 °C

With borane-THF; water; phosphorus tribromide; sodium hydride; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;