Technology Process of (3S,7aR)-6-(3-chlorophenoxy)-7-furan-3-yl-2,2-dimethyl-5-oxo-7-phenyl-2,3,5,7a-tetrahydro-pyrrolo[2,1-b]thiazole-3-carboxylic acid benzhydryl ester
There total 6 articles about (3S,7aR)-6-(3-chlorophenoxy)-7-furan-3-yl-2,2-dimethyl-5-oxo-7-phenyl-2,3,5,7a-tetrahydro-pyrrolo[2,1-b]thiazole-3-carboxylic acid benzhydryl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
bis-triphenylphosphine-palladium(II) chloride; cetyldimethylbenzylammonium chloride; cesium fluoride;
In
water; toluene;
for 3h;
Reflux;
Inert atmosphere;
DOI:10.1002/jhet.550
- Guidance literature:
-
Multi-step reaction with 3 steps
1: acetic acid; sodium chloride / ethanol; water / 20 °C
2: dichloromethane / 20 °C
3: bis-triphenylphosphine-palladium(II) chloride; cetyldimethylbenzylammonium chloride; cesium fluoride / water; toluene / 3 h / Reflux; Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; cetyldimethylbenzylammonium chloride; acetic acid; cesium fluoride; sodium chloride;
In
ethanol; dichloromethane; water; toluene;
3: Suzuki-Miyaura coupling;
DOI:10.1002/jhet.550
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium hydroxide / water / 3 h / 20 °C
2: acetic acid; sodium chloride / ethanol; water / 20 °C
3: dichloromethane / 20 °C
4: bis-triphenylphosphine-palladium(II) chloride; cetyldimethylbenzylammonium chloride; cesium fluoride / water; toluene / 3 h / Reflux; Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; cetyldimethylbenzylammonium chloride; acetic acid; cesium fluoride; sodium chloride; potassium hydroxide;
In
ethanol; dichloromethane; water; toluene;
4: Suzuki-Miyaura coupling;
DOI:10.1002/jhet.550
