1-{3-fluoro-4-[(sulfamoylamino)methyl]phenyl}-3-{[2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl}urea

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Chemical Name:1-{3-fluoro-4-[(sulfamoylamino)methyl]phenyl}-3-{[2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl}urea
CAS No.:1428790-00-4
Molecular Formula:C₁₉H₂₂F₄N₆O₃S
Molecular Weight:490.482
Hs Code.:

Synonyms:1-{3-fluoro-4-[(sulfamoylamino)methyl]phenyl}-3-{[2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl}urea

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Chemical Property of 1-{3-fluoro-4-[(sulfamoylamino)methyl]phenyl}-3-{[2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl}urea

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-{3-fluoro-4-[(sulfamoylamino)methyl]phenyl}-3-{[2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl}urea

There total 8 articles about 1-{3-fluoro-4-[(sulfamoylamino)methyl]phenyl}-3-{[2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl}urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1428790-37-7
tert-butyl N-(2-fluoro-4-(3-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)sulfamoylcarbamate

: 1428790-00-4
1-{3-fluoro-4-[(sulfamoylamino)methyl]phenyl}-3-{[2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl}urea

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 23 ℃; for 2.5h;

Reference yield:

: 127349-56-8
1-(bromomethyl)-2-fluoro-4-nitrobenzene

: 1428790-00-4
1-{3-fluoro-4-[(sulfamoylamino)methyl]phenyl}-3-{[2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl}urea

Guidance literature:: Multi-step reaction with 7 steps

1: N,N-dimethyl-formamide / 18 h / 20 °C

2: hydrazine hydrate; p-toluenesulfonic acid monohydrate / tetrahydrofuran / 6 h / Reflux

3: triethylamine / dichloromethane / 3.5 h / 20 - 50 °C

4: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 6 h / 20 °C

5: pyridine / tetrahydrofuran; acetonitrile / 1 h / 0 - 20 °C

6: dmap / acetonitrile / 50 °C

7: trifluoroacetic acid / dichloromethane / 2.5 h / 0 - 20 °C

With pyridine; dmap; palladium 10% on activated carbon; p-toluenesulfonic acid monohydrate; hydrogen; hydrazine hydrate; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 1427-07-2
2-fluoro-4-nitrotoluene

: 1428790-00-4
1-{3-fluoro-4-[(sulfamoylamino)methyl]phenyl}-3-{[2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl]methyl}urea

Guidance literature:: Multi-step reaction with 8 steps

1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 18 h / Reflux

2: N,N-dimethyl-formamide / 18 h / 20 °C

3: hydrazine hydrate; p-toluenesulfonic acid monohydrate / tetrahydrofuran / 6 h / Reflux

4: triethylamine / dichloromethane / 3.5 h / 20 - 50 °C

5: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 6 h / 20 °C

6: pyridine / tetrahydrofuran; acetonitrile / 1 h / 0 - 20 °C

7: dmap / acetonitrile / 50 °C

8: trifluoroacetic acid / dichloromethane / 2.5 h / 0 - 20 °C

With pyridine; dmap; N-Bromosuccinimide; palladium 10% on activated carbon; p-toluenesulfonic acid monohydrate; hydrogen; hydrazine hydrate; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; acetonitrile;