1-(BROMOMETHYL)-2-FLUORO-4-NITROBENZENE

Base Information

• Chemical Name: 1-(BROMOMETHYL)-2-FLUORO-4-NITROBENZENE
• CAS No.: 127349-56-8
• Molecular Formula: C7H5BrFNO2
• Molecular Weight: 234.025
• Hs Code.: 2904909090
• Mol file: 127349-56-8.mol

Synonyms:4-bromomethyl-3-fluoronitrobenzene;2-FLUORO-4'-NITROBENZOPHENONE;1-Bromomethyl-2-fluoro-4-nitro-benzene;(2-fluorophenyl){4-nitrophenyl}methanone;2-fluoro-4-nitrobenzyl bromide;4-(bromomethyl)-3-fluoro-1-nitrobenzene;

Chemical Property of 1-(BROMOMETHYL)-2-FLUORO-4-NITROBENZENE

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Boiling Point: 304.085oC at 760 mmHg
• Flash Point: 137.706oC
• PSA: 45.82000
• LogP: 3.15200

Purity/Quality:

99%, ^*data from raw suppliers

1-(Bromomethyl)-2-fluoro-4-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(BROMOMETHYL)-2-FLUORO-4-NITROBENZENE

There total 3 articles about 1-(BROMOMETHYL)-2-FLUORO-4-NITROBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-fluoro-4-nitrotoluene (1427-07-2) → 1-(bromomethyl)-2-fluoro-4-nitrobenzene (127349-56-8)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 18h; UV-irradiation; Reflux;

Reference yield: 85.0%

(2-fluoro-4-nitrophenyl)methanol (660432-43-9) → 1-(bromomethyl)-2-fluoro-4-nitrobenzene (127349-56-8)

Guidance literature:

With N-Bromosuccinimide; triphenylphosphine; In dichloromethane; at 0 - 23 ℃; for 2h;

Reference yield:

2-fluoro-4-nitro-benzoic acid methyl ester (392-09-6) → 1-(bromomethyl)-2-fluoro-4-nitrobenzene (127349-56-8)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol; sodium tetrahydroborate / 4 h / 23 °C

2: N-Bromosuccinimide; triphenylphosphine / dichloromethane / 2 h / 0 - 23 °C

With methanol; sodium tetrahydroborate; N-Bromosuccinimide; triphenylphosphine; In dichloromethane;

upstream raw materials:

2-fluoro-4-nitrotoluene

2-fluoro-4-nitro-benzoic acid methyl ester

(2-fluoro-4-nitrophenyl)methanol

Downstream raw materials:

[1-(4-amino-2-fluorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl]acetic acid methyl ester

(1-(2-fluoro-4-[(1H-indole-2-carbonyl)amino]benzyl)-3,5-dimethyl-1H-pyrazol-4-yl)acetic acid

(1-(2-fluoro-4-[(1H-indole-2-carbonyl)amino]benzyl)-3,5-dimethyl-1H-pyrazol-4-yl)acetic acid methyl ester

(1-(2-fluoro-4-[(5-fluoro-3-methylbenzofuran-2-carbonyl)amino]benzyl)-3,5-dimethyl-1H-pyrazol-4-yl)acetic acid methyl ester

Refernces

• 1、 -. "NITROGENOUS HETEROCYCLIC DERIVATIVES AND THEIR APPLICATION IN DRUGS". Page/Page column 121. . Retrieved 2018/06/01.
• 2、 -. "Nitrogenous Heterocyclic Derivatives And Their Application In Drugs". Paragraph 0504. . Retrieved 2015/03/31.