5-tert-butyl-2-(2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenyl)isoindolin-1-one

Base Information

Chemical Name:5-tert-butyl-2-(2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenyl)isoindolin-1-one
CAS No.:1361940-86-4
Molecular Formula:C₃₅H₃₇N₅O₄
Molecular Weight:591.71
Hs Code.:

Synonyms:5-tert-butyl-2-(2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenyl)isoindolin-1-one

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Chemical Property of 5-tert-butyl-2-(2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenyl)isoindolin-1-one

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Technology Process of 5-tert-butyl-2-(2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenyl)isoindolin-1-one

There total 13 articles about 5-tert-butyl-2-(2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenyl)isoindolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1361940-85-3
4-tert-butyl-2-((2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)-phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenylamino)methyl)benzoic acid

: 1361940-86-4
5-tert-butyl-2-(2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenyl)isoindolin-1-one

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 98-73-7
4-(1,1-dimethylethyl)benzoic acid

: 1361940-86-4
5-tert-butyl-2-(2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenyl)isoindolin-1-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / cyclohexane; tetrahydrofuran / 1 h / -92 °C

1.2: 0.17 h / -80 °C

2.1: N,N-dimethyl-formamide / dichloromethane / 8 h / 20 °C

2.2: 0.5 h

3.1: dibenzoyl peroxide; N-Bromosuccinimide / benzene / 4 h / Reflux

4.1: N-ethyl-N,N-diisopropylamine / ethanol / 16 h / 100 °C / Sealed tube

5.1: lithium hydroxide / ethanol; water; tetrahydrofuran / 16 h / 60 °C

5.2: pH 7

6.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

With N-Bromosuccinimide; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; dibenzoyl peroxide; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; dichloromethane; cyclohexane; water; N,N-dimethyl-formamide; benzene;

Reference yield:

2-bromo-6-nitrotoluene: 55289-35-5
2-bromo-6-nitrotoluene

: 1361940-86-4
5-tert-butyl-2-(2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenyl)isoindolin-1-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 20.5 h / 85 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / methanol / 13 h / 20 °C

3.1: sodium carbonate / 1,4-dioxane; water / 0.25 h / Inert atmosphere

3.2: 38 h / 100 °C

4.1: N-ethyl-N,N-diisopropylamine / ethanol / 16 h / 100 °C / Sealed tube

5.1: lithium hydroxide / ethanol; water; tetrahydrofuran / 16 h / 60 °C

5.2: pH 7

6.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

With hydrogen; potassium acetate; sodium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 3.1: Suzuki Coupling;