4-tert-butyl-2-((2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)-phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenylamino)methyl)benzoic acid

Base Information

Chemical Name:4-tert-butyl-2-((2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)-phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenylamino)methyl)benzoic acid
CAS No.:1361940-85-3
Molecular Formula:C₃₅H₃₉N₅O₅
Molecular Weight:609.725
Hs Code.:

Synonyms:4-tert-butyl-2-((2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)-phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenylamino)methyl)benzoic acid

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Chemical Property of 4-tert-butyl-2-((2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)-phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenylamino)methyl)benzoic acid

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Technology Process of 4-tert-butyl-2-((2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)-phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenylamino)methyl)benzoic acid

There total 12 articles about 4-tert-butyl-2-((2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)-phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenylamino)methyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1361940-83-1
ethyl 4-tert-butyl-2-((2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)phenyl amino)-5-oxo-4,5-dihydropyrazin-2-yl)phenylamino)methyl)benzoate

: 1361940-85-3
4-tert-butyl-2-((2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)-phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenylamino)methyl)benzoic acid

Guidance literature:: ethyl 4-tert-butyl-2-((2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)phenyl amino)-5-oxo-4,5-dihydropyrazin-2-yl)phenylamino)methyl)benzoate; With lithium hydroxide; In tetrahydrofuran; ethanol; water; at 60 ℃; for 16h;

With hydrogenchloride; In tetrahydrofuran; ethanol; water; pH=7;

Reference yield:

: 98-73-7
4-(1,1-dimethylethyl)benzoic acid

: 1361940-85-3
4-tert-butyl-2-((2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)-phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenylamino)methyl)benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / cyclohexane; tetrahydrofuran / 1 h / -92 °C

1.2: 0.17 h / -80 °C

2.1: N,N-dimethyl-formamide / dichloromethane / 8 h / 20 °C

2.2: 0.5 h

3.1: dibenzoyl peroxide; N-Bromosuccinimide / benzene / 4 h / Reflux

4.1: N-ethyl-N,N-diisopropylamine / ethanol / 16 h / 100 °C / Sealed tube

5.1: lithium hydroxide / ethanol; water; tetrahydrofuran / 16 h / 60 °C

5.2: pH 7

With N-Bromosuccinimide; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; N-ethyl-N,N-diisopropylamine; lithium hydroxide; dibenzoyl peroxide; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; dichloromethane; cyclohexane; water; benzene;

Reference yield:

2-bromo-6-nitrotoluene: 55289-35-5
2-bromo-6-nitrotoluene

: 1361940-85-3
4-tert-butyl-2-((2-methyl-3-(4-methyl-6-(4-(morpholine-4-carbonyl)-phenylamino)-5-oxo-4,5-dihydropyrazin-2-yl)phenylamino)methyl)benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 20.5 h / 85 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / methanol / 13 h / 20 °C

3.1: sodium carbonate / 1,4-dioxane; water / 0.25 h / Inert atmosphere

3.2: 38 h / 100 °C

4.1: N-ethyl-N,N-diisopropylamine / ethanol / 16 h / 100 °C / Sealed tube

5.1: lithium hydroxide / ethanol; water; tetrahydrofuran / 16 h / 60 °C

5.2: pH 7

With hydrogen; potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; dimethyl sulfoxide; 3.1: Suzuki Coupling;