N-(4-fluorobenzyl)-4-[2-({4-[(1-hydroxy-2-methylpropan-2-yl)carbamoyl]-2-methoxyphenyl}amino)[1,2,4]triazolo[1,5-a]pyridin-6-yl]-2-methylbenzamide

Base Information

Chemical Name:N-(4-fluorobenzyl)-4-[2-({4-[(1-hydroxy-2-methylpropan-2-yl)carbamoyl]-2-methoxyphenyl}amino)[1,2,4]triazolo[1,5-a]pyridin-6-yl]-2-methylbenzamide
CAS No.:1403331-01-0
Molecular Formula:C₃₃H₃₃FN₆O₄
Molecular Weight:596.661
Hs Code.:

Synonyms:N-(4-fluorobenzyl)-4-[2-({4-[(1-hydroxy-2-methylpropan-2-yl)carbamoyl]-2-methoxyphenyl}amino)[1,2,4]triazolo[1,5-a]pyridin-6-yl]-2-methylbenzamide

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Chemical Property of N-(4-fluorobenzyl)-4-[2-({4-[(1-hydroxy-2-methylpropan-2-yl)carbamoyl]-2-methoxyphenyl}amino)[1,2,4]triazolo[1,5-a]pyridin-6-yl]-2-methylbenzamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(4-fluorobenzyl)-4-[2-({4-[(1-hydroxy-2-methylpropan-2-yl)carbamoyl]-2-methoxyphenyl}amino)[1,2,4]triazolo[1,5-a]pyridin-6-yl]-2-methylbenzamide

There total 5 articles about N-(4-fluorobenzyl)-4-[2-({4-[(1-hydroxy-2-methylpropan-2-yl)carbamoyl]-2-methoxyphenyl}amino)[1,2,4]triazolo[1,5-a]pyridin-6-yl]-2-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1309682-38-9
4-bromo-N-(1-hydroxy-2-methylpropan-2-yl)-3-methoxybenzamide

: 1352620-85-9
4-(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)-N-(4-fluorobenzyl)-2-methyl-benzamide

: 1403331-01-0
N-(4-fluorobenzyl)-4-[2-({4-[(1-hydroxy-2-methylpropan-2-yl)carbamoyl]-2-methoxyphenyl}amino)[1,2,4]triazolo[1,5-a]pyridin-6-yl]-2-methylbenzamide

Guidance literature:: With potassium phosphate; chloro(2-dicyclohexylphosphino-2’,4’,6’-tri-i-propyl-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct; XPhos; In 1-methyl-pyrrolidin-2-one; toluene; at 130 ℃; for 2h; Inert atmosphere; Sealed tube;

Reference yield:

: 17100-63-9
methyl 4-bromo-3-methoxybenzoate

: 1403331-01-0
N-(4-fluorobenzyl)-4-[2-({4-[(1-hydroxy-2-methylpropan-2-yl)carbamoyl]-2-methoxyphenyl}amino)[1,2,4]triazolo[1,5-a]pyridin-6-yl]-2-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; lithium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C

1.2: pH 4 / Cooling with ice

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

3.1: dichloromethane / 3 h / 20 °C

4.1: potassium phosphate / XPhos; chloro(2-dicyclohexylphosphino-2’,4’,6’-tri-i-propyl-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct / toluene; 1-methyl-pyrrolidin-2-one / 2 h / 130 °C / Inert atmosphere; Sealed tube

With potassium phosphate; oxalyl dichloride; water; lithium hydroxide; chloro(2-dicyclohexylphosphino-2’,4’,6’-tri-i-propyl-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct; N,N-dimethyl-formamide; XPhos; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; toluene;

Reference yield:

: 56256-14-5
4-bromo-3-methoxy-benzoic acid

: 1403331-01-0
N-(4-fluorobenzyl)-4-[2-({4-[(1-hydroxy-2-methylpropan-2-yl)carbamoyl]-2-methoxyphenyl}amino)[1,2,4]triazolo[1,5-a]pyridin-6-yl]-2-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

2: dichloromethane / 3 h / 20 °C

3: potassium phosphate / XPhos; chloro(2-dicyclohexylphosphino-2’,4’,6’-tri-i-propyl-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct / toluene; 1-methyl-pyrrolidin-2-one / 2 h / 130 °C / Inert atmosphere; Sealed tube

With potassium phosphate; oxalyl dichloride; chloro(2-dicyclohexylphosphino-2’,4’,6’-tri-i-propyl-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct; N,N-dimethyl-formamide; XPhos; In 1-methyl-pyrrolidin-2-one; dichloromethane; toluene;