4-(Benzyloxy)pyridine

Base Information

• Chemical Name: 4-(Benzyloxy)pyridine
• CAS No.: 49826-70-2
• Molecular Formula: C12H11 N O
• Molecular Weight: 185.225
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID50490134
• Nikkaji Number: J1.759.101K
• Wikidata: Q72442552
• Mol file: 49826-70-2.mol

Synonyms:4-(Benzyloxy)pyridine;49826-70-2;4-Benzyloxypyridine;4-phenylmethoxypyridine;MFCD08235112;4-BENZYLOXY-PYRIDINE;PYRIDINE, 4-(PHENYLMETHOXY)-;Pyridine,4-(phenylmethoxy)-;4-benzyloxy pyridine;SCHEMBL953509;4-[(Phenylmethyl)oxy]pyridine;DTXSID50490134;WBCDUONHBLSZED-UHFFFAOYSA-N;ZBA82670;AKOS005255192;AB43755;DS-7147;SY025692;CS-0144122;FT-0650048;A852307;F2199-0592

Chemical Property of 4-(Benzyloxy)pyridine

Chemical Property:

• Vapor Pressure: 0.00111mmHg at 25°C
• Melting Point: 57-58℃
• Refractive Index: 1.577
• Boiling Point: 310℃
• PKA: 6.58±0.10(Predicted)
• Flash Point: 114℃
• PSA: 22.12000
• Density: 1.106
• LogP: 2.66060
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 185.084063974
• Heavy Atom Count: 14
• Complexity: 148

Purity/Quality:

97% ^*data from raw suppliers

4-(Benzyloxy)pyridine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=CC=NC=C2

Technology Process of 4-(Benzyloxy)pyridine

There total 7 articles about 4-(Benzyloxy)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-chlorpyridine hydrochloride (7379-35-3) + benzyl alcohol (100-51-6,185532-71-2) → 4-(benzyloxy)pyridine (49826-70-2)

Guidance literature:

benzyl alcohol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h;

4-chlorpyridine hydrochloride; In N,N-dimethyl-formamide; mineral oil; at 80 ℃; for 24h;

DOI:10.1021/acs.joc.7b02775

Reference yield: 95.0%

→ 4-(benzyloxy)pyridine (49826-70-2)

Guidance literature:

Reference yield: 87.0%

4-benzyloxypyridine-N-oxide (2683-66-1) → 4-(benzyloxy)pyridine (49826-70-2)

Guidance literature:

With 2,3-dimethyl-2,3-butane diol; bis(N,N-dimethylacetamide)dichloridodioxidomolybdenum(VI); In N,N-dimethyl acetamide; at 130 ℃; Microwave irradiation; Sealed tube; Green chemistry;

DOI:10.1002/adsc.201700071

upstream raw materials:

4-benzyloxypyridine-N-oxide

pyridin-4-ol

benzyl chloride

1-(4-pyridyl)pyridinium chloride hydrochloride

Downstream raw materials:

4-benzyloxypyridine-N-oxide

pyridin-4-ol

ethyl 5-(benzyloxy)-2-methylpyrazolo[1,5-a]pyridine-3-carboxylate

1-(5-benzyloxypyrazolo[1,5-a]pyridin-3-yl)ethanone