6-fluoro-1-(4-hydroxyphenyl)-1H-indol-4-ol

Base Information

Chemical Name:6-fluoro-1-(4-hydroxyphenyl)-1H-indol-4-ol
CAS No.:1181566-66-4
Molecular Formula:C₁₄H₁₀FNO₂
Molecular Weight:243.237
Hs Code.:

Synonyms:6-fluoro-1-(4-hydroxyphenyl)-1H-indol-4-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-fluoro-1-(4-hydroxyphenyl)-1H-indol-4-ol

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Technology Process of 6-fluoro-1-(4-hydroxyphenyl)-1H-indol-4-ol

There total 5 articles about 6-fluoro-1-(4-hydroxyphenyl)-1H-indol-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1181567-00-9
6-fluoro-1-{4-[(phenylmethyl)oxy]phenyl}-1H-indol-4-ol

: 1181566-66-4
6-fluoro-1-(4-hydroxyphenyl)-1H-indol-4-ol

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 3h;

Reference yield:

: 1181566-93-7
(E)-2-(2-bromo-4-fluoro-6-nitrophenyl)-N,N-dimethylethenamine

: 1181566-66-4
6-fluoro-1-(4-hydroxyphenyl)-1H-indol-4-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid; zinc / water / 5 h / 75 - 85 °C

2.1: oxygen; triethylamine / copper diacetate / dichloromethane / 16 h / 20 °C

3.1: water; potassium hydroxide; tert-butyl XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1.5 h / 85 °C

3.2: pH 7

4.1: hydrogen / palladium on activated charcoal / ethanol / 3 h / 20 °C

With water; hydrogen; oxygen; acetic acid; triethylamine; potassium hydroxide; zinc; tert-butyl XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on activated charcoal; copper diacetate; In 1,4-dioxane; ethanol; dichloromethane; water;

Reference yield:

: 885520-70-7
4-bromo-6-fluoro-1H-indole

: 1181566-66-4
6-fluoro-1-(4-hydroxyphenyl)-1H-indol-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxygen; triethylamine / copper diacetate / dichloromethane / 16 h / 20 °C

2.1: water; potassium hydroxide; tert-butyl XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1.5 h / 85 °C

2.2: pH 7

3.1: hydrogen / palladium on activated charcoal / ethanol / 3 h / 20 °C

With water; hydrogen; oxygen; triethylamine; potassium hydroxide; tert-butyl XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on activated charcoal; copper diacetate; In 1,4-dioxane; ethanol; dichloromethane;