Technology Process of (E)-2-(2-bromo-4-fluoro-6-nitrophenyl)-N,N-dimethylethenamine
There total 1 articles about (E)-2-(2-bromo-4-fluoro-6-nitrophenyl)-N,N-dimethylethenamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyrrolidine;
In
N,N-dimethyl-formamide;
at 110 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: acetic acid; zinc / water / 5 h / 75 - 85 °C
2: oxygen; triethylamine / copper diacetate / dichloromethane / 72 h / 20 °C / Molecular sieve
With
oxygen; acetic acid; triethylamine; zinc;
copper diacetate;
In
dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: acetic acid; zinc / water / 5 h / 75 - 85 °C
2.1: oxygen; triethylamine / copper diacetate / dichloromethane / 16 h / 20 °C
3.1: water; potassium hydroxide; tert-butyl XPhos / tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 1.5 h / 85 °C
3.2: pH 7
4.1: hydrogen / palladium on activated charcoal / ethanol / 3 h / 20 °C
With
water; hydrogen; oxygen; acetic acid; triethylamine; potassium hydroxide; zinc; tert-butyl XPhos;
tris-(dibenzylideneacetone)dipalladium(0); palladium on activated charcoal; copper diacetate;
In
1,4-dioxane; ethanol; dichloromethane; water;
