1-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-{4-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-butylamino}-ethanol

Base Information

Chemical Name:1-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-{4-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-butylamino}-ethanol
CAS No.:459867-18-6
Molecular Formula:C₃₆H₆₅NO₄Si₃
Molecular Weight:660.173
Hs Code.:

1-[3,4-bis-(<i>tert</i>-butyl-dimethyl-silanyloxy)-phenyl]-2-{4-[4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-phenyl]-butylamino}-ethanol

Synonyms:1-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-{4-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-butylamino}-ethanol

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Chemical Property of 1-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-{4-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-butylamino}-ethanol

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Technology Process of 1-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-{4-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-butylamino}-ethanol

There total 8 articles about 1-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-{4-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-butylamino}-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 459867-17-5
N-{2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-hydroxy-ethyl}-4-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-butyramide

: 459867-18-6
1-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-{4-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-butylamino}-ethanol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 41 ℃; for 12h;
DOI:10.1021/ol020077n

Reference yield:

: 99815-16-4
3,4-bis(tert-butyldimethylsilanyloxy)benzaldehyde

: 459867-18-6
1-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-{4-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-butylamino}-ethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2,6-bis((2R-(dinaphthyl(OH)C)pyrrolidino)Me)-4-MePheOH; Et₂Zn / tetrahydrofuran / 24 h / -35 °C

2.1: 99 percent / H₂ / Pd/C / methanol / 3 h

3.1: diphenyl chlorophosphate; diisopropylethylamine / CH₂Cl₂ / 2 h

3.2: 75 percent / diisopropylethylamine / CH₂Cl₂ / 1 h / -78 - 20 °C

4.1: 92 percent / LiAlH₄ / diethyl ether / 12 h / 41 °C

With lithium aluminium tetrahydride; hydrogen; N-ethyl-N,N-diisopropylamine; chlorophosphoric acid diphenyl ester; palladium on activated charcoal; 2,6-bis((2R-(dinaphthyl(OH)C)pyrrolidino)Me)-4-MePheOH; diethylzinc; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 1.1: Henry reaction;
DOI:10.1021/ol020077n

Reference yield:

: 205587-34-4
(R)-1-(3,4-di(t-butyldimethylsiloxy)phenyl)-2-nitroethanol

: 459867-18-6
1-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-{4-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-butylamino}-ethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 99 percent / H₂ / Pd/C / methanol / 3 h

2.1: diphenyl chlorophosphate; diisopropylethylamine / CH₂Cl₂ / 2 h

2.2: 75 percent / diisopropylethylamine / CH₂Cl₂ / 1 h / -78 - 20 °C

3.1: 92 percent / LiAlH₄ / diethyl ether / 12 h / 41 °C

With lithium aluminium tetrahydride; hydrogen; N-ethyl-N,N-diisopropylamine; chlorophosphoric acid diphenyl ester; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/ol020077n