tetrahydro-2-<<4-<2-(ethoxycarbonyl)pyridin-3-yl>phenyl>methoxy>-2H-pyran

Base Information

• Chemical Name: tetrahydro-2-<<4-<2-(ethoxycarbonyl)pyridin-3-yl>phenyl>methoxy>-2H-pyran
• CAS No.: 164460-52-0
• Molecular Formula: C₂₀H₂₃NO₄
• Molecular Weight: 341.407
• Mol file: 164460-52-0.mol

Synonyms:tetrahydro-2-<<4-<2-(ethoxycarbonyl)pyridin-3-yl>phenyl>methoxy>-2H-pyran

Chemical Property of tetrahydro-2-<<4-<2-(ethoxycarbonyl)pyridin-3-yl>phenyl>methoxy>-2H-pyran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tetrahydro-2-<<4-<2-(ethoxycarbonyl)pyridin-3-yl>phenyl>methoxy>-2H-pyran

There total 1 articles about tetrahydro-2-<<4-<2-(ethoxycarbonyl)pyridin-3-yl>phenyl>methoxy>-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

<4-<<(tetrahydro-2H-pyran-2-yl)oxy>methyl>phenyl>boronic acid (164460-51-9) + ethyl 3-<<(trifluoromethyl)-sulfonyl>oxy>pyridine-2-carboxylate (164460-55-3) → tetrahydro-2-<<4-<2-(ethoxycarbonyl)pyridin-3-yl>phenyl>methoxy>-2H-pyran (164460-52-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; Yield given. Multistep reaction; 1.) 1,2-DME, RT, 30 min, 2.) 1,2-DME, reflux;

DOI:10.1021/jm00049a012

Reference yield: 92.0%

tetrahydro-2-<<4-<2-(ethoxycarbonyl)pyridin-3-yl>phenyl>methoxy>-2H-pyran (164460-52-0) → ethyl 3-<4-(hydroxymethyl)phenyl>pyridine-2-carboxylate (164460-31-5)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; Heating;

DOI:10.1021/jm00049a012

Reference yield:

tetrahydro-2-<<4-<2-(ethoxycarbonyl)pyridin-3-yl>phenyl>methoxy>-2H-pyran (164460-52-0) → 3-[4-(2-Butyl-5-chloro-4-hydroxymethyl-imidazol-1-ylmethyl)-phenyl]-pyridine-2-carboxylic acid ethyl ester (164460-45-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / p-TsOH*H₂O / methanol / Heating

2: 1.) 1N HCl, 2.) thionyl chloride / 1.) EtOH, 2.) CHCl₃, RT

3: 1.) NaH / 1.) DMF, 1 h, 2.) DMF, 25 deg C, 16 h

With hydrogenchloride; thionyl chloride; sodium hydride; toluene-4-sulfonic acid; In methanol;

DOI:10.1021/jm00049a012

upstream raw materials:

<4-<<(tetrahydro-2H-pyran-2-yl)oxy>methyl>phenyl>boronic acid

ethyl 3-<<(trifluoromethyl)-sulfonyl>oxy>pyridine-2-carboxylate

Downstream raw materials:

ethyl 3-<4-(hydroxymethyl)phenyl>pyridine-2-carboxylate

3-(4-Chloromethyl-phenyl)-pyridine-2-carboxylic acid ethyl ester

3-[4-(2-Butyl-5-chloro-4-hydroxymethyl-imidazol-1-ylmethyl)-phenyl]-pyridine-2-carboxylic acid ethyl ester

2-butyl-4-chloro-5-(hydroxymethyl)-1-<<1-<2-(ethoxycarbonyl)pyridin-3-yl>-4-phenyl>methyl>-1H-imidazole