164460-51-9

Upstream product

• 17100-68-4 2-((4-bromobenzyl)oxy)tetrahydro-2H-pyran 
• 873-75-6 4-bromobenzenemethanol 
• 7732-18-5 water 
• 110-87-2 3,4-dihydro-2H-pyran 

Downstream Products

• 59016-93-2 p-hydroxymethylphenylboronic acid 
• 164460-49-5 2-butyl-4-chloro-5-(hydroxymethyl)-1-<<1-<4-(ethoxycarbonyl)pyridin-3-yl>-4-phenyl>methyl>-1H-imidazole 
• 164460-44-0 2-butyl-4-chloro-5-(hydroxymethyl)-1-<<1-<2-(ethoxycarbonyl)pyridin-3-yl>-4-phenyl>methyl>-1H-imidazole 
• 164460-46-2 2-butyl-4-chloro-5-(hydroxymethyl)-1-<<1-<3-(ethoxycarbonyl)pyridin-2-yl>-4-phenyl>methyl>-1H-imidazole 
• 164460-50-8 2-butyl-4-chloro-5-formyl-1-<<1-<4-(ethoxycarbonyl)pyridin-3-yl>-4-phenyl>methyl>-1H-imidazole 
• 164460-47-3 2-[4-(2-Butyl-5-chloro-4-hydroxymethyl-imidazol-1-ylmethyl)-phenyl]-nicotinic acid ethyl ester 
• 164460-45-1 3-[4-(2-Butyl-5-chloro-4-hydroxymethyl-imidazol-1-ylmethyl)-phenyl]-pyridine-2-carboxylic acid ethyl ester 
• 164460-33-7 ethyl 3-<4-(hydroxymethyl)phenyl>pyridine-4-carboxylate 
• 164460-31-5 ethyl 3-<4-(hydroxymethyl)phenyl>pyridine-2-carboxylate 
• 164460-32-6 ethyl 2-<4-(hydroxymethyl)phenyl>pyridine-3-carboxylate 
• 164460-37-1 3-(4-Chloromethyl-phenyl)-isonicotinic acid ethyl ester 
• 164460-35-9 3-(4-Chloromethyl-phenyl)-pyridine-2-carboxylic acid ethyl ester 
• 164460-36-0 2-(4-Chloromethyl-phenyl)-nicotinic acid ethyl ester 
• 326496-51-9 (4-(acetoxymethyl)phenyl)boronic acid 

Relevant academic research and scientific papers

NOVEL LIQUID CRYSTALLINE COMPOUND AND LIQUID CRYSTAL COMPOSITION PREPARED USING THE SAME

PROBLEM TO BE SOLVED: To provide a liquid crystal compound that has a low viscosity, a high isotropic transition temperature, a high compatibility, and a high refractive index anisotropy, and is also resistant to degradation due to heat and light. SOLUTION: The present invention illustrates a naphthalene derivative represented by the general formula (1), specifically, for example, a naphthalene derivative obtained through a reaction represented by the following formula, as well as a liquid crystal composition comprising the same. Use of the liquid crystal composition comprising the liquid crystal compound makes it possible to provide a high-speed response liquid crystal display element. COPYRIGHT: (C)2016,JPOandINPIT

A convergent asymmetric synthesis of a growth hormone secretagogue

Described herein is a convergent asymmetric synthesis of growth hormone secretagogue (GHS) suitable for large-scale preparations. Key features include: (1) an improved method for α-iodination of a lactam; (2) a novel synthesis of a disubstituted urea usin

Zinc borates: Functionalized hard nucleophiles for coupling reactions with secondary allylic acetates

We have succeeded in developing zinc borates of the general structure 3 for coupling reaction with allylic acetates. The advantages of using compounds 3 are their compatibility with carbonyl groups such as aldehyde, ketone, and ester groups, and their high reactivity toward secondary allylic acetates. Zinc borates 3 were prepared from boronate esters 1 [R(T) = p-(CHO)C6H4, p-(Ac)C6H4, p-{Ac(CH2)2}C6H4, p-(Ac-OCH2)C6H4, p-{AcO(CH2)3}C6H4, p-{EtO2C(CH2}2}C6H4, (E)-CH=CH(CH2)4OAc] with MeZnCl; subsequent treatment with allylic acetates 4 [R = n-C5H11, c-C6H11, (CH2)2CH(-O(CH2}2O-)] in the presence of NiCl2(PPh3)2 (10 mol-%) in THF-DMI (1,3-dimethyl-2-imidazolidinone) (10 equiv.) at 40-50 °C overnight furnished the coupling products 5 in good yields. Among the products, 5bb, possessing one free and one protected aldehyde group, is a highlight of this type of reaction. The stereochemical aspects of the reaction were also examined. Thus, the alkenyl groups of (E)- and (Z)-alkenyl borates 3b and c were transformed with retention of the olefinic geometry into acetates 4a and b (R = n-C5H11, c-C6H11), while reaction of cyclic acetate 11 proceeded with inversion at the carbon center involved in the reaction. In addition, we found that the anions generated from (EtO)2P(= O)CH2CO2Et and (MeO)2P(=O)CH2Ac under Masamune's conditions attacked the aldehyde carbon in the boronate 1d to produce - after reduction of the double bond - the boronate esters 1i and 1j, respectively, in good yields.