(1R,2S,3R,4S)-3-[2-(3-Methoxycarbonyl-propyl)-benzyl]-7-oxa-bicyclo[2.2.1]heptane-2-carboxylic acid

Base Information

Chemical Name:(1R,2S,3R,4S)-3-[2-(3-Methoxycarbonyl-propyl)-benzyl]-7-oxa-bicyclo[2.2.1]heptane-2-carboxylic acid
CAS No.:149079-90-3
Molecular Formula:C₁₉H₂₄O₅
Molecular Weight:332.397
Hs Code.:

Synonyms:(1R,2S,3R,4S)-3-[2-(3-Methoxycarbonyl-propyl)-benzyl]-7-oxa-bicyclo[2.2.1]heptane-2-carboxylic acid

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Chemical Property of (1R,2S,3R,4S)-3-[2-(3-Methoxycarbonyl-propyl)-benzyl]-7-oxa-bicyclo[2.2.1]heptane-2-carboxylic acid

Chemical Property:

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Technology Process of (1R,2S,3R,4S)-3-[2-(3-Methoxycarbonyl-propyl)-benzyl]-7-oxa-bicyclo[2.2.1]heptane-2-carboxylic acid

There total 1 articles about (1R,2S,3R,4S)-3-[2-(3-Methoxycarbonyl-propyl)-benzyl]-7-oxa-bicyclo[2.2.1]heptane-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 135613-44-4
<1S-1α,2α,3α,4α>-2-<<3-(hydroxymethyl)-7-oxabicyclo<2.2.1>hept-2-yl>methyl>benzenebutanoic acid, methyl ester

: 149079-90-3
(1R,2S,3R,4S)-3-[2-(3-Methoxycarbonyl-propyl)-benzyl]-7-oxa-bicyclo[2.2.1]heptane-2-carboxylic acid

Guidance literature:: With chromium(VI) oxide; sulfuric acid; In acetone; at 25 ℃;
DOI:10.1021/jm00062a013

Reference yield:

: 130776-17-9
N-(4-cyclohexylbutyl)-L-serinamide

: 149079-90-3
(1R,2S,3R,4S)-3-[2-(3-Methoxycarbonyl-propyl)-benzyl]-7-oxa-bicyclo[2.2.1]heptane-2-carboxylic acid

: 1026878-22-7
4-(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-hydroxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl}-phenyl)-butyric acid methyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 0 - 25 ℃;
DOI:10.1021/jm00062a013

Reference yield:

: 149079-90-3
(1R,2S,3R,4S)-3-[2-(3-Methoxycarbonyl-propyl)-benzyl]-7-oxa-bicyclo[2.2.1]heptane-2-carboxylic acid

: 4-(2-{(1S,2R,3S,4R)-3-[4-(4-Cyclohexyl-butylcarbamoyl)-oxazol-2-yl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl}-phenyl)-butyric acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1-hydroxybenzotriazole, Et₃N, ethyl (3-(dimethylamino)propyl)carbodiimide hydrochloride / dimethylformamide / 0 - 25 °C

2: PPh₃, CCl₄, (iPr)2NEt / acetonitrile; CH₂Cl₂ / 25 °C

3: CuBr₂, DBU / ethyl acetate; CHCl₃ / 25 °C

4: LiOH, H₂O / tetrahydrofuran / 25 °C

With tetrachloromethane; lithium hydroxide; water; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; copper(ll) bromide; In tetrahydrofuran; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00062a013