Technology Process of methyl (2R,3R,E)-2-(((2R,4S,5R)-2-(4-chlorophenyl)-4-vinyl-1,3-dioxan-5-yl)oxy)-3-(4-methoxyphenoxy)hex-5-enoate
There total 19 articles about methyl (2R,3R,E)-2-(((2R,4S,5R)-2-(4-chlorophenyl)-4-vinyl-1,3-dioxan-5-yl)oxy)-3-(4-methoxyphenoxy)hex-5-enoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl (2R,3R,E)-2-(((2R,4S,5R)-2-(4-chlorophenyl)-4-vinyl-1,3-dioxan-5-yl)oxy)-6-hydroxy-3-(4-methoxyphenoxy)hex-4-enoate;
With
1-hexene; di-isopropyl azodicarboxylate; N-isopropylidene-N’-2-nitrobenzenesulfonyl hydrazine; triphenylphosphine;
In
tetrahydrofuran;
at 0 - 17 ℃;
for 10h;
With
2,2,2-trifluoroethanol;
In
tetrahydrofuran; water;
at 17 ℃;
for 19h;
DOI:10.1016/j.tet.2016.12.041
- Guidance literature:
-
C26H29ClO8;
With
1-hexene; N-isopropylidene-N’-2-nitrobenzenesulfonyl hydrazine; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran;
at 26 ℃;
With
2,2,2-trifluoroethanol; water;
at 26 ℃;
DOI:10.1016/j.tetlet.2012.12.001
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 27 °C
2.1: potassium hexamethylsilazane; chloro-trimethyl-silane / tetrahydrofuran / 0.25 h / -78 °C
3.1: benzene; methanol / 26 °C
4.1: water; hydrogenchloride / acetonitrile / 0 °C
5.1: sodium periodate / tetrahydrofuran / 25 °C / pH 7
6.1: sodium tetrahydroborate; cerium(III) chloride heptahydrate / methanol / -78 °C
7.1: N-isopropylidene-N’-2-nitrobenzenesulfonyl hydrazine; triphenylphosphine; diethylazodicarboxylate; 1-hexene / tetrahydrofuran / 26 °C
7.2: 26 °C
With
hydrogenchloride; dmap; sodium tetrahydroborate; sodium periodate; chloro-trimethyl-silane; 1-hexene; cerium(III) chloride heptahydrate; N-isopropylidene-N’-2-nitrobenzenesulfonyl hydrazine; water; potassium hexamethylsilazane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; dichloromethane; acetonitrile; benzene;
DOI:10.1016/j.tetlet.2012.12.001
