(S,Z)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3-(4-methoxyphenoxy)allyl 2-(((2R,4S,5R)-2-(4-chlorophenyl)-4-vinyl-1,3-dioxan-5-yl)oxy)acetate

Base Information

Chemical Name:(S,Z)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3-(4-methoxyphenoxy)allyl 2-(((2R,4S,5R)-2-(4-chlorophenyl)-4-vinyl-1,3-dioxan-5-yl)oxy)acetate
CAS No.:1421257-52-4
Molecular Formula:C₂₉H₃₃ClO₉
Molecular Weight:561.029
Hs Code.:

Synonyms:(S,Z)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3-(4-methoxyphenoxy)allyl 2-(((2R,4S,5R)-2-(4-chlorophenyl)-4-vinyl-1,3-dioxan-5-yl)oxy)acetate

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Chemical Property of (S,Z)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3-(4-methoxyphenoxy)allyl 2-(((2R,4S,5R)-2-(4-chlorophenyl)-4-vinyl-1,3-dioxan-5-yl)oxy)acetate

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Technology Process of (S,Z)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3-(4-methoxyphenoxy)allyl 2-(((2R,4S,5R)-2-(4-chlorophenyl)-4-vinyl-1,3-dioxan-5-yl)oxy)acetate

There total 10 articles about (S,Z)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3-(4-methoxyphenoxy)allyl 2-(((2R,4S,5R)-2-(4-chlorophenyl)-4-vinyl-1,3-dioxan-5-yl)oxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1421257-51-3
2-(((2R,4S,5R)-2-(4-chlorophenyl)-4-vinyl-1,3-dioxan-5-yl)oxy)acetic acid

: 1421257-49-9
(S,Z)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3-(4-methoxyphenoxy)prop-2-en-1-ol

: 1421257-52-4
(S,Z)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3-(4-methoxyphenoxy)allyl 2-(((2R,4S,5R)-2-(4-chlorophenyl)-4-vinyl-1,3-dioxan-5-yl)oxy)acetate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 22 ℃; for 18h;
DOI:10.1016/j.tet.2016.12.041

Reference yield:

: 150-76-5
4-methoxy-phenol

: 1421257-52-4
(S,Z)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3-(4-methoxyphenoxy)allyl 2-(((2R,4S,5R)-2-(4-chlorophenyl)-4-vinyl-1,3-dioxan-5-yl)oxy)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride; potassium iodide / tetrahydrofuran / 60 °C

2.1: n-butyllithium / diethyl ether / 0 °C

2.2: 0 - 25 °C

3.1: hydrogen / benzene / 23 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 27 °C

With dmap; n-butyllithium; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide; In tetrahydrofuran; diethyl ether; dichloromethane; benzene;
DOI:10.1016/j.tetlet.2012.12.001

Reference yield:

: 1-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-3-(4-methoxyphenoxy)prop-2-yn-1-ol

: 1421257-52-4
(S,Z)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3-(4-methoxyphenoxy)allyl 2-(((2R,4S,5R)-2-(4-chlorophenyl)-4-vinyl-1,3-dioxan-5-yl)oxy)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / benzene / 23 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 27 °C

With dmap; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; benzene;
DOI:10.1016/j.tetlet.2012.12.001