C₁₂H₁₅FO₂

Base Information

• Chemical Name: C₁₂H₁₅FO₂
• CAS No.: 289032-98-0
• Molecular Formula: C₁₂H₁₅FO₂
• Molecular Weight: 210.248
• Mol file: 289032-98-0.mol

Synonyms:C₁₂H₁₅FO₂

Chemical Property of C₁₂H₁₅FO₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of C₁₂H₁₅FO₂

There total 2 articles about C₁₂H₁₅FO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C12H17FO2 (1383151-09-4) → C12H15FO2 (289032-98-0)

Guidance literature:

With silica gel; pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1021/jm300171v

Reference yield:

1-bromo-6-hexanol (4286-55-9) → C12H15FO2 (289032-98-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

2: silica gel; pyridinium chlorochromate / dichloromethane / 4 h / 20 °C / Inert atmosphere

With silica gel; potassium carbonate; pyridinium chlorochromate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm300171v

Reference yield: 96.0%

1,5-dideoxy-1,5-imino-D-glucitol (19130-96-2) + C12H15FO2 (289032-98-0) → (2R,3R,4R,5S)-1-(6-(4-fluorophenoxy)hexyl)-2-(hydroxymethyl)piperidine-3,4,5-triol (1383152-27-9)

Guidance literature:

1,5-dideoxy-1,5-imino-D-glucitol; With acetic acid; at 20 ℃;

C₁₂H₁₅FO₂; With acetic acid; In ethanol; at 20 ℃; for 1h; Inert atmosphere;

With palladium 10% on activated carbon; hydrogen; In ethanol; for 24h;

DOI:10.1021/jm300171v

upstream raw materials:

C₁₂H₁₇FO₂

1-bromo-6-hexanol

Downstream raw materials:

(2R,3R,4R,5S)-1-(6-(4-fluorophenoxy)hexyl)-2-(hydroxymethyl)piperidine-3,4,5-triol