(2E,4E)-5-{p-methoxybenzyl-[2-(3-indolyl)-ethyl]-amino}-penta-2,4-dienal

Base Information

• Chemical Name: (2E,4E)-5-{p-methoxybenzyl-[2-(3-indolyl)-ethyl]-amino}-penta-2,4-dienal
• CAS No.: 1132757-67-5
• Molecular Formula: C₂₃H₂₄N₂O₂
• Molecular Weight: 360.456
• Mol file: 1132757-67-5.mol

Synonyms:(2E,4E)-5-{p-methoxybenzyl-[2-(3-indolyl)-ethyl]-amino}-penta-2,4-dienal

Chemical Property of (2E,4E)-5-{p-methoxybenzyl-[2-(3-indolyl)-ethyl]-amino}-penta-2,4-dienal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2E,4E)-5-{p-methoxybenzyl-[2-(3-indolyl)-ethyl]-amino}-penta-2,4-dienal

There total 2 articles about (2E,4E)-5-{p-methoxybenzyl-[2-(3-indolyl)-ethyl]-amino}-penta-2,4-dienal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-(1H-indol-3-yl)-N-(4-methoxybenzyl)ethan-1-amine (7390-67-2) + (2E,4E)-5-hydroxypenta-2,4-dienal potassium salt (40418-44-8) → (2E,4E)-5-{p-methoxybenzyl-[2-(3-indolyl)-ethyl]-amino}-penta-2,4-dienal (1132757-67-5)

Guidance literature:

With trifluoroacetic acid; In acetonitrile; at 0 - 23 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2016.11.004

Reference yield: 40.0%

1-(2,4-dinitrophenyl)-pyridinium chloride (4185-69-7) + 2-(1H-indol-3-yl)-N-(4-methoxybenzyl)ethan-1-amine (7390-67-2) → (2E,4E)-5-{p-methoxybenzyl-[2-(3-indolyl)-ethyl]-amino}-penta-2,4-dienal (1132757-67-5)

Guidance literature:

1-(2,4-dinitrophenyl)-pyridinium chloride; 2-(1H-indol-3-yl)-N-(4-methoxybenzyl)ethan-1-amine; In ethanol; Reflux; Inert atmosphere;

With sodium hydroxide; In water; Inert atmosphere;

DOI:10.1016/j.tet.2016.11.004

Reference yield: 89.0%

(2E,4E)-5-{p-methoxybenzyl-[2-(3-indolyl)-ethyl]-amino}-penta-2,4-dienal (1132757-67-5) → C23H24N2O2

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 80 ℃; Inert atmosphere; Sealed tube;

DOI:10.1016/j.tet.2016.11.004

upstream raw materials:

1-(2,4-dinitrophenyl)-pyridinium chloride

2-(1H-indol-3-yl)-N-(4-methoxybenzyl)ethan-1-amine

(2E,4E)-5-hydroxypenta-2,4-dienal potassium salt