2-(1H-indol-3-yl)-N-(4-methoxybenzyl)ethanamine

Base Information

• Chemical Name: 2-(1H-indol-3-yl)-N-(4-methoxybenzyl)ethanamine
• CAS No.: 7390-67-2
• Molecular Formula: C18H20N2O
• Molecular Weight: 280.37
• Mol file: 7390-67-2.mol

Synonyms:CHEMBRDG-BB 5559004;2-(1H-INDOL-3-YL)-N-(4-METHOXYBENZYL)ETHANAMINE;2-(1H-indol-3-yl)-N-(4-methoxybenzyl)ethanamine(SALTDATA: HBr)

Chemical Property of 2-(1H-indol-3-yl)-N-(4-methoxybenzyl)ethanamine

Chemical Property:

• Vapor Pressure: 3.32E-09mmHg at 25°C
• Boiling Point: 475.5°C at 760 mmHg
• Flash Point: 241.3°C
• Density: 1.145g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(1H-indol-3-yl)-N-(4-methoxybenzyl)ethanamine

There total 6 articles about 2-(1H-indol-3-yl)-N-(4-methoxybenzyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

tryptamine (61-54-1) + 4-methoxy-benzaldehyde (123-11-5) → 2-(1H-indol-3-yl)-N-(4-methoxybenzyl)ethan-1-amine (7390-67-2)

Guidance literature:

tryptamine; 4-methoxy-benzaldehyde; In methanol; at 20 ℃; for 24h; Molecular sieve; Inert atmosphere;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/acs.joc.9b02114

Reference yield:

tryptamine (93879-05-1) → 2-(1H-indol-3-yl)-N-(4-methoxybenzyl)ethan-1-amine (7390-67-2)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 0.5h; Inert atmosphere;

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → 2-(1H-indol-3-yl)-N-(4-methoxybenzyl)ethan-1-amine (7390-67-2)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 16.5 h / 20 °C / Inert atmosphere

2: sodium tetrahydroborate / methanol / 0.5 h / Inert atmosphere

With sodium tetrahydroborate; In methanol;

DOI:10.1021/jacs.5b04686

upstream raw materials:

tryptamine

4-methoxy-benzaldehyde

tryptamine

Downstream raw materials:

(2E,4E)-5-{p-methoxybenzyl-[2-(3-indolyl)-ethyl]-amino}-penta-2,4-dienal