N¹-cholesteryloxycarbonyl-1-amino-2''-nitrobenzenesulfonamidoethane

Base Information

• Chemical Name: N¹-cholesteryloxycarbonyl-1-amino-2''-nitrobenzenesulfonamidoethane
• CAS No.: 851219-16-4
• Molecular Formula: C₃₆H₅₅N₃O₆S
• Molecular Weight: 657.915
• Mol file: 851219-16-4.mol

Synonyms:N¹-cholesteryloxycarbonyl-1-amino-2''-nitrobenzenesulfonamidoethane

Chemical Property of N¹-cholesteryloxycarbonyl-1-amino-2''-nitrobenzenesulfonamidoethane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N¹-cholesteryloxycarbonyl-1-amino-2''-nitrobenzenesulfonamidoethane

There total 3 articles about N¹-cholesteryloxycarbonyl-1-amino-2''-nitrobenzenesulfonamidoethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-Nitrobenzenesulfonamide (5455-59-4) + N1-cholesteryloxycarbonyl-1-amino-2-hydroxyethane (136099-11-1) → N1-cholesteryloxycarbonyl-1-amino-2''-nitrobenzenesulfonamidoethane (851219-16-4)

Guidance literature:

With 2-(diphenylphosphino)pyridine; di-tert-butyl-diazodicarboxylate; In dichloromethane; for 2h;

DOI:10.1039/b418168a

Reference yield: 70.0%

N-(2-aminoethyl)-2-nitrobenzene-sulfonamide (83019-91-4) + Cholesteryl chloroformate (7144-08-3) → N1-cholesteryloxycarbonyl-1-amino-2''-nitrobenzenesulfonamidoethane (851219-16-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1248/bpb.b14-00526

Reference yield:

Cholesteryl chloroformate (7144-08-3) → N1-cholesteryloxycarbonyl-1-amino-2''-nitrobenzenesulfonamidoethane (851219-16-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / CH₂Cl₂ / 18 h / 20 °C

2: 90 percent / diphenyl-2-pyridylphosphine; di-tert-butyl azodicarboxylate / CH₂Cl₂ / 2 h

With 2-(diphenylphosphino)pyridine; di-tert-butyl-diazodicarboxylate; In dichloromethane;

DOI:10.1039/b418168a

upstream raw materials:

2-Nitrobenzenesulfonamide

N¹-cholesteryloxycarbonyl-1-amino-2-hydroxyethane

Cholesteryl chloroformate

N-(2-aminoethyl)-2-nitrobenzene-sulfonamide

Downstream raw materials:

cholesteryl (2-((2-hydroxyethyl)amino)ethyl)carbamate

N¹-cholesteryloxycarbonyl-3-aza-N³-t-butoxycarbonyl-6,9,12-trioxa-1-amino-15-O¹⁵-4''-nitrophenyloxycarbonyltetradecane

N¹-cholesteryloxycarbonyl-3-aza-N³-2''-nitrobenzenesulfonyl-6,9,12-trioxa-15-benzyloxy-1-amino-tetradecane