Butyric acid 5,5-difluoro-2-{hydroxy-[2-(trityl-amino)-ethoxy]-phosphoryloxymethyl}-4-oxo-heptyl ester

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Chemical Name:Butyric acid 5,5-difluoro-2-{hydroxy-[2-(trityl-amino)-ethoxy]-phosphoryloxymethyl}-4-oxo-heptyl ester
CAS No.:102047-00-7
Molecular Formula:C₃₃H₄₀F₂NO₇P
Molecular Weight:631.654
Hs Code.:

Synonyms:Butyric acid 5,5-difluoro-2-{hydroxy-[2-(trityl-amino)-ethoxy]-phosphoryloxymethyl}-4-oxo-heptyl ester

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Chemical Property of Butyric acid 5,5-difluoro-2-{hydroxy-[2-(trityl-amino)-ethoxy]-phosphoryloxymethyl}-4-oxo-heptyl ester

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Technology Process of Butyric acid 5,5-difluoro-2-{hydroxy-[2-(trityl-amino)-ethoxy]-phosphoryloxymethyl}-4-oxo-heptyl ester

There total 8 articles about Butyric acid 5,5-difluoro-2-{hydroxy-[2-(trityl-amino)-ethoxy]-phosphoryloxymethyl}-4-oxo-heptyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 24070-16-4
N-tritylethanolamine

: 102046-99-1
Butyric acid 5,5-difluoro-4-oxo-2-phosphonooxymethyl-heptyl ester

: 102047-00-7
Butyric acid 5,5-difluoro-2-{hydroxy-[2-(trityl-amino)-ethoxy]-phosphoryloxymethyl}-4-oxo-heptyl ester

Guidance literature:: With triisopropylbenzenesulfonyl chloride; In chloroform; at 25 ℃;
DOI:10.1021/ja00271a077

Reference yield:

: 5-Bromomethyl-2-isopropyl-[1,3]dioxane

: 102047-00-7
Butyric acid 5,5-difluoro-2-{hydroxy-[2-(trityl-amino)-ethoxy]-phosphoryloxymethyl}-4-oxo-heptyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) t-BuLi / 1.) Et₂O, -78 deg C; 2.) Et₂O, -78 deg C to -25 deg C

2: 100 percent / 1 N HCl / dioxane / 25 °C

3: 90 percent / pyridine / CHCl₃ / 0 °C

4: 66 percent / NaBH₄ / ethanol / 25 °C

5: pyridine / 25 °C

6: CrO₃*(pyridine)2 / CH₂Cl₂ / 25 °C

7: H₂ / PtO₂ / methanol / 25 °C

8: 45 percent / triisopropylbenzenesulfonyl chloride / CHCl₃ / 25 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; triisopropylbenzenesulfonyl chloride; hydrogen; tert.-butyl lithium; dipyridine chromium trioxide; platinum(IV) oxide; In 1,4-dioxane; pyridine; methanol; ethanol; dichloromethane; chloroform;
DOI:10.1021/ja00271a077

Reference yield:

: 2-(1,1-Difluoro-propyl)-4-hydroxymethyl-tetrahydro-furan-2-ol

: 102047-00-7
Butyric acid 5,5-difluoro-2-{hydroxy-[2-(trityl-amino)-ethoxy]-phosphoryloxymethyl}-4-oxo-heptyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / pyridine / CHCl₃ / 0 °C

2: 66 percent / NaBH₄ / ethanol / 25 °C

3: pyridine / 25 °C

4: CrO₃*(pyridine)2 / CH₂Cl₂ / 25 °C

5: H₂ / PtO₂ / methanol / 25 °C

6: 45 percent / triisopropylbenzenesulfonyl chloride / CHCl₃ / 25 °C

With pyridine; sodium tetrahydroborate; triisopropylbenzenesulfonyl chloride; hydrogen; dipyridine chromium trioxide; platinum(IV) oxide; In pyridine; methanol; ethanol; dichloromethane; chloroform;
DOI:10.1021/ja00271a077