N-(2-(1H-indol-3-yl)ethyl)-2-(4-fluorophenyl)-2-oxoacetamide

Base Information

• Chemical Name: N-(2-(1H-indol-3-yl)ethyl)-2-(4-fluorophenyl)-2-oxoacetamide
• CAS No.: 1281506-78-2
• Molecular Formula: C₁₈H₁₅FN₂O₂
• Molecular Weight: 310.328
• Mol file: 1281506-78-2.mol

Synonyms:N-(2-(1H-indol-3-yl)ethyl)-2-(4-fluorophenyl)-2-oxoacetamide

Chemical Property of N-(2-(1H-indol-3-yl)ethyl)-2-(4-fluorophenyl)-2-oxoacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-(1H-indol-3-yl)ethyl)-2-(4-fluorophenyl)-2-oxoacetamide

There total 1 articles about N-(2-(1H-indol-3-yl)ethyl)-2-(4-fluorophenyl)-2-oxoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

tryptamine (61-54-1) + α,α-Dibromo-4'-fluoroacetophenone (7542-64-5) → N-(2-(1H-indol-3-yl)ethyl)-2-(4-fluorophenyl)-2-oxoacetamide (1281506-78-2) + 4-fluoro-N-(2-indol-3-yl-ethyl)-benzamide (2803-63-6)

Guidance literature:

α,α-Dibromo-4'-fluoroacetophenone; With sodium iodide; In dimethyl sulfoxide; at 25 - 45 ℃; Inert atmosphere;

tryptamine; With triethylamine; In dimethyl sulfoxide; at 25 - 45 ℃; Inert atmosphere;

With Cumene hydroperoxide; In hexane; dimethyl sulfoxide; at 25 - 45 ℃; Inert atmosphere;

DOI:10.3762/bjoc.10.45

Reference yield: 25.0%

N-(2-(1H-indol-3-yl)ethyl)-2-(4-fluorophenyl)-2-oxoacetamide (1281506-78-2) → (2,9-dihydro-1H-pyrido[3,4-b]indol-1-yl)(4-fluorophenyl)methanone + (4-fluorophenyl)(1-hydroxy-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)methanone

Guidance literature:

N-(2-(1H-indol-3-yl)ethyl)-2-(4-fluorophenyl)-2-oxoacetamide; With boron trifluoride diethyl etherate; In diethyl ether; at 25 - 30 ℃; for 2h; Inert atmosphere;

In diethyl ether; toluene; at 55 - 70 ℃; Inert atmosphere;

DOI:10.3762/bjoc.10.45

upstream raw materials:

tryptamine

α,α-Dibromo-4'-fluoroacetophenone

Refernces