1-(2,2-difluoro-2-(phenylthio)ethyl)-4-((4-methylbenzamido)methyl)-1H-1,2,3-triazole

Base Information

Chemical Name:1-(2,2-difluoro-2-(phenylthio)ethyl)-4-((4-methylbenzamido)methyl)-1H-1,2,3-triazole
CAS No.:1292210-33-3
Molecular Formula:C₁₉H₁₈F₂N₄OS
Molecular Weight:388.441
Hs Code.:

Synonyms:1-(2,2-difluoro-2-(phenylthio)ethyl)-4-((4-methylbenzamido)methyl)-1H-1,2,3-triazole

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Chemical Property of 1-(2,2-difluoro-2-(phenylthio)ethyl)-4-((4-methylbenzamido)methyl)-1H-1,2,3-triazole

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Technology Process of 1-(2,2-difluoro-2-(phenylthio)ethyl)-4-((4-methylbenzamido)methyl)-1H-1,2,3-triazole

There total 4 articles about 1-(2,2-difluoro-2-(phenylthio)ethyl)-4-((4-methylbenzamido)methyl)-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1262850-20-3
2,2-difluoro-2-(phenylthio)ethan-1-ol

: 82225-34-1
4-methyl-N-(prop-2-yn-1-yl)benzamide

: 1292210-33-3
1-(2,2-difluoro-2-(phenylthio)ethyl)-4-((4-methylbenzamido)methyl)-1H-1,2,3-triazole

Guidance literature:: 2,2-difluoro-2-(phenylthio)ethan-1-ol; With sodium azide; tetra-(n-butyl)ammonium iodide; triethylamine; N-tosylimidazole; In N,N-dimethyl-formamide; at 100 ℃; for 10h;

4-methyl-N-(prop-2-yn-1-yl)benzamide; With copper(l) iodide; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1002/adsc.201000791

Reference yield:

: 101068-11-5
ethyl 2,2-difluoro-2-(phenylthio)acetate

: 1292210-33-3
1-(2,2-difluoro-2-(phenylthio)ethyl)-4-((4-methylbenzamido)methyl)-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

2.1: sodium azide; tetra-(n-butyl)ammonium iodide; triethylamine; N-tosylimidazole / N,N-dimethyl-formamide / 10 h / 100 °C

2.2: 20 °C

With lithium aluminium tetrahydride; sodium azide; tetra-(n-butyl)ammonium iodide; triethylamine; N-tosylimidazole; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/adsc.201000791

Reference yield:

: 108-98-5
thiophenol

: 1292210-33-3
1-(2,2-difluoro-2-(phenylthio)ethyl)-4-((4-methylbenzamido)methyl)-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 1 h / 40 °C

1.2: 15 h / 40 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

3.1: sodium azide; tetra-(n-butyl)ammonium iodide; triethylamine; N-tosylimidazole / N,N-dimethyl-formamide / 10 h / 100 °C

3.2: 20 °C

With lithium aluminium tetrahydride; sodium azide; tetra-(n-butyl)ammonium iodide; sodium hydride; triethylamine; N-tosylimidazole; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/adsc.201000791