1262850-20-3

Upstream product

• 108-98-5 thiophenol 
• 667-27-6 Ethyl bromodifluoroacetate 
• 101068-11-5 ethyl 2,2-difluoro-2-(phenylthio)acetate 

Downstream Products

• 699-12-7 2-(phenylthio)ethanol 
• 1292210-30-0 1-(2,2-difluoro-2-(phenylthio)ethyl)-4-((2,6-di-tert-butyl-4-methylphenoxy)methyl)-1H-1,2,3-triazole 
• 1292210-34-4 1-(2,2-difluoro-2-(phenylthio)ethyl)-4-((3,5-dimethylbenzamido)methyl)-1H-1,2,3-triazole 
• 1292210-27-5 1-(2,2-difluoro-2-(phenylthio)ethyl)-4-((2-methylphenoxy)methyl)-1H-1,2,3-triazole 
• 1292210-23-1 1-(2,2-difluoro-2-(phenylthio)ethyl)-4-(3-methylphenyl)-1H-1,2,3-triazole 
• 1292210-25-3 1-(2,2-difluoro-2-(phenylthio)ethyl)-4-(phenoxymethyl)-1H-1,2,3-triazole 
• 1292210-28-6 1-(2,2-difluoro-2-(phenylthio)ethyl)-4-((4-methylphenoxy)methyl)-1H-1,2,3-triazole 
• 1292210-31-1 1-(2,2-difluoro-2-(phenylthio)ethyl)-4-((naphthalen-1-yloxy)methyl)-1H-1,2,3-triazole 
• 1292210-29-7 1-(2,2-difluoro-2-(phenylthio)ethyl)-4-((4-tert-butylphenoxy)methyl)-1H-1,2,3-triazole 
• 1292210-21-9 1-(2,2-difluoro-2-(phenylthio)ethyl)-4-phenyl-1H-1,2,3-triazole 
• 1292210-24-2 1-(2,2-difluoro-2-(phenylthio)ethyl)-4-(4-methoxyphenyl)-1H-1,2,3-triazole 
• 1292210-32-2 1-(2,2-difluoro-2-(phenylthio)ethyl)-4-((benzamido)methyl)-1H-1,2,3-triazole 
• 1292210-26-4 1-(2,2-difluoro-2-(phenylthio)ethyl)-4-((4-fluorophenoxy)methyl)-1H-1,2,3-triazole 
• 1292210-33-3 1-(2,2-difluoro-2-(phenylthio)ethyl)-4-((4-methylbenzamido)methyl)-1H-1,2,3-triazole 

Relevant academic research and scientific papers

Catalytic Enantioselective Cyclopropenation of Internal Alkynes: Access to Difluoromethylated Three-Membered Carbocycles

Herein we described an efficient RhII-catalyzed enantioselective cyclopropenation reaction of internal alkynes with a masked difluorodiazoethane reagent (PhSO2CF2CHN2, Ps-DFA). This asymmetric transformation offers efficient access to a broad range of enantioenriched difluoromethylated cyclopropenes (40 examples, up to 99 % yield, 97 % ee). The synthetic utility of obtained strained carbocycles is demonstrated by subsequent stereodefined processes, including cross-couplings, hydrogenation, Diels–Alder reaction, and Pauson–Khand reaction.

Cu(I)-Catalyzed gem-Aminoalkynylation of Diazo Compounds: Synthesis of Fluorinated Propargylic Amines

The gem-aminoalkynylation of fluorinated diazo compounds catalyzed by a simple Cu(I) salt is described. This three-component reaction allows the synthesis of propargylic amines with broad functional group tolerance. Both electron-rich and electron-poor an

Synthesis method of 1, 1-difluoro-2-isonitrile-ethyl phenyl sulfone compound

The invention discloses a synthesis method of a 1, 1-difluoro-2-isonitrile-ethyl phenyl sulfone compound. The synthesis method is characterized in that the 1, 1-difluoro-2-isonitrile-ethyl phenyl sulfone compound is synthesized from a 2, 2-difluoro-2-(thi

Non-catalytic conversion of C-F bonds of gem-difluoromethylene derivatives to C-H bonds with lithium aluminum hydride under room temperature

An unexpected hydrodefluorination of unactivated aliphatic C-F bonds of CF2 derivatives with LiAlH4 at room temperature without any added metal catalyst was reported. Deuterium-labeling experiments suggested that the hydrogens introduced into the products originated from LiAlH 4. Copyright

Novel synthesis of difluoromethyl-containing 1,4-disubstituted 1,2,3-triazoles via a click-multicomponent reaction and desulfanylation strategy

Fourteen difluoromethyl-containing 1,4-disubstituted 1,2,3-triazoles were synthesized via a novel copper-catalyzed click-multicomponent reaction of 2,2-difluoro-2-phenylsulfanylethanol, sodium azide and terminal alkynes in the presence of N-(p-toluenesulf