N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-2H-inden-1-yl)hexyl)hydroxylamine

Base Information

Chemical Name:N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-2H-inden-1-yl)hexyl)hydroxylamine
CAS No.:1188931-93-2
Molecular Formula:C₃₆H₆₉NO₃Si₂
Molecular Weight:620.12
Hs Code.:

N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-2H-inden-1-yl)hexyl)hydroxylamine

Synonyms:N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-2H-inden-1-yl)hexyl)hydroxylamine

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Chemical Property of N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-2H-inden-1-yl)hexyl)hydroxylamine

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Technology Process of N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-2H-inden-1-yl)hexyl)hydroxylamine

There total 5 articles about N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-2H-inden-1-yl)hexyl)hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 957214-13-0
(5S)-5-((1R,3R,7E,17β)-1,3-bis[tert-butyl(dimethyl)silyloxy]-9,10-secoestra-5,7-dien-17-yl)hexanal

: 1188931-93-2
N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-2H-inden-1-yl)hexyl)hydroxylamine

Guidance literature:: (5S)-5-((1R,3R,7E,17β)-1,3-bis[tert-butyl(dimethyl)silyloxy]-9,10-secoestra-5,7-dien-17-yl)hexanal; With hydroxylamine; In water; toluene; for 0.5h; Reflux;

With sodium cyanoborohydride; acetic acid; In tetrahydrofuran; at 0 ℃;

With sodium hydroxide; In tetrahydrofuran; Alkaline conditions;

Reference yield:

: C₃₆H₆₇NO₃Si₂

: 1188931-93-2
N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-2H-inden-1-yl)hexyl)hydroxylamine

Guidance literature:: C₃₆H₆₇NO₃Si₂; With sodium cyanoborohydride; acetic acid; In tetrahydrofuran; at 0 ℃; for 1h;

With sodium hydroxide; In tetrahydrofuran;
DOI:10.1016/j.bmc.2010.03.078

Reference yield:

: (S)-5-((1R,3aR,4S,7aR)-4-(tert-butyldimethylsilyloxy)-7a-methyloctahydro-1H-inden-1-yl)-1-ethoxyhex-1-ene

: 1188931-93-2
N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-2H-inden-1-yl)hexyl)hydroxylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridinium chlorochromate / dichloromethane / 3 h / Molecular sieve

1.2: 24 h / 20 °C

1.3: 3 h / 20 °C / Molecular sieve

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere; Cooling with ice

2.2: 3.08 h / -78 - 20 °C / Inert atmosphere

2.3: Saturated solution

3.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 - 20 °C / Inert atmosphere

4.1: hydroxylamine / water; toluene / 0.5 h / Reflux

4.2: 0 °C

4.3: Alkaline conditions

With hydroxylamine; sodium hexamethyldisilazane; diisobutylaluminium hydride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; water; toluene;