N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)hexyl)-N-hydroxyformamide

Base Information

Chemical Name:N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)hexyl)-N-hydroxyformamide
CAS No.:1188931-82-9
Molecular Formula:C₂₅H₄₁NO₄
Molecular Weight:419.605
Hs Code.:

Synonyms:N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)hexyl)-N-hydroxyformamide

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Chemical Property of N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)hexyl)-N-hydroxyformamide

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Technology Process of N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)hexyl)-N-hydroxyformamide

There total 5 articles about N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)hexyl)-N-hydroxyformamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 32042-38-9
2,2,2-trifluoroethyl formate

: 1188931-93-2
N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-2H-inden-1-yl)hexyl)hydroxylamine

: 1188931-82-9
N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)hexyl)-N-hydroxyformamide

Guidance literature:: 2,2,2-trifluoroethyl formate; N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-2H-inden-1-yl)hexyl)hydroxylamine; With formic acid; In tetrahydrofuran; Reflux;

With hydrogen fluoride; In dichloromethane; acetonitrile; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In dichloromethane; acetonitrile; Saturated solution;

Reference yield:

: C₃₇H₆₉NO₄Si₂

: 1188931-82-9
N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)hexyl)-N-hydroxyformamide

Guidance literature:: With hydrogen fluoride; In dichloromethane; acetonitrile; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2010.03.078

Reference yield:

: 957214-13-0
(5S)-5-((1R,3R,7E,17β)-1,3-bis[tert-butyl(dimethyl)silyloxy]-9,10-secoestra-5,7-dien-17-yl)hexanal

: 1188931-82-9
N-((R)-5-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)hexyl)-N-hydroxyformamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydroxylamine / water; toluene / 0.5 h / Reflux

1.2: 0 °C

1.3: Alkaline conditions

2.1: formic acid / tetrahydrofuran / Reflux

2.2: 2 h / 20 °C

2.3: Saturated solution

With formic acid; hydroxylamine; In tetrahydrofuran; water; toluene;