6-methoxy-2-(4-fluoro-phenyl)-pyrazolo[1, 5-b]pyridazine-3-carboxylic acid

Base Information

• Chemical Name: 6-methoxy-2-(4-fluoro-phenyl)-pyrazolo[1, 5-b]pyridazine-3-carboxylic acid
• CAS No.: 221148-28-3
• Molecular Formula: C₁₄H₁₀FN₃O₃
• Molecular Weight: 287.25

Synonyms:6-methoxy-2-(4-fluoro-phenyl)-pyrazolo[1, 5-b]pyridazine-3-carboxylic acid

Chemical Property of 6-methoxy-2-(4-fluoro-phenyl)-pyrazolo[1, 5-b]pyridazine-3-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-methoxy-2-(4-fluoro-phenyl)-pyrazolo[1, 5-b]pyridazine-3-carboxylic acid

There total 2 articles about 6-methoxy-2-(4-fluoro-phenyl)-pyrazolo[1, 5-b]pyridazine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-methoxy-2-(4-fluoro-phenyl)-pyrazolo[1,5-b]pyridazine-3-carboxylic acid methyl ester (221148-27-2) → 6-methoxy-2-(4-fluoro-phenyl)-pyrazolo[1, 5-b]pyridazine-3-carboxylic acid (221148-28-3)

Guidance literature:

With sodium hydroxide; In ethanol; Heating;

DOI:10.1016/j.bmcl.2004.07.089

Reference yield:

methyl 3-(4-fluorophenyl)propiolate (42122-44-1) → 6-methoxy-2-(4-fluoro-phenyl)-pyrazolo[1, 5-b]pyridazine-3-carboxylic acid (221148-28-3)

Guidance literature:

Multi-step reaction with 2 steps

1: DBU / acetonitrile / 25 °C

2: aq. NaOH / ethanol / Heating

With sodium hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol; acetonitrile;

DOI:10.1016/j.bmcl.2004.07.089

Reference yield:

6-methoxy-2-(4-fluoro-phenyl)-pyrazolo[1, 5-b]pyridazine-3-carboxylic acid (221148-28-3) → 3-bromo-2-(4-fluoro-phenyl)-6-methoxy-pyrazolo[1,5-b]pyridazine

Guidance literature:

With N-Bromosuccinimide; sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 25 ℃;

DOI:10.1016/j.bmcl.2004.07.089

upstream raw materials:

6-methoxy-2-(4-fluoro-phenyl)-pyrazolo[1,5-b]pyridazine-3-carboxylic acid methyl ester

methyl 3-(4-fluorophenyl)propiolate

Downstream raw materials:

2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-6-methoxy-pyrazolo[1,5-b]pyridazine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 221148-28-3 6-methoxy-2-(4-fluoro-phenyl)-pyrazolo[1, 5-b]pyridazine-3-carboxylic acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send