42122-44-1

Basic information

• Product Name: Methyl 3-(4-fluorophenyl)prop-2-ynoate
• Synonyms: Methyl 3-(4-fluorophenyl)prop-2-ynoate;Methyl 3-(4-fluorophenyl)propiolate
• CAS NO: 42122-44-1
• Molecular Formula: C₁₀H₇FO₂
• Molecular Weight: 178.1597832
• EINECS: -0
• Mol File: 42122-44-1.mol
• Article Data: 30

Chemical Properties

• Boiling Point: 243.797°C at 760 mmHg
• Flash Point: 98.375°C
• Appearance: /
• Density: 1.209g/cm³
• Vapor Pressure: 0.031mmHg at 25°C
• Refractive Index: 1.526
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: Methyl 3-(4-fluorophenyl)prop-2-ynoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-(4-fluorophenyl)prop-2-ynoate(42122-44-1)
• EPA Substance Registry System: Methyl 3-(4-fluorophenyl)prop-2-ynoate(42122-44-1)

Safety Data

• Hazardous Substances Data: 42122-44-1(Hazardous Substances Data)

Usage

General Description

Methyl 3-(4-fluorophenyl)prop-2-ynoate is a chemical compound with the formula C11H9FO2. It is a colorless liquid with a molecular weight of 182.19 g/mol. The compound is commonly used as a building block in organic synthesis and pharmaceutical research. It is known to exhibit antifungal and antibacterial properties, making it a potential candidate for the development of new drugs. Methyl 3-(4-fluorophenyl)prop-2-ynoate is also used in the manufacture of materials such as plastics and adhesives. However, it is important to handle this compound with caution, as it may cause skin and eye irritation upon contact.

InChI:InChI=1/C10H7FO2/c1-13-10(12)7-4-8-2-5-9(11)6-3-8/h2-3,5-6H,1H3

Upstream product

• 79-22-1 methyl chloroformate 
• 130995-12-9 1-(4-fluorophenyl)-2-trimethylsilylacetylene 
• 403-43-0 4-fluorobenzoyl chloride 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 63131-29-3 methyl 4-fluorobenzoyl acetate 
• 67-56-1 methanol 
• 706-06-9 3-(4-flurophenyl)prop-2-ynoic acid 
• 77-78-1 dimethyl sulfate 
• 766-98-3 1-ethynyl-4-fluorobenzene 
• 1033721-15-1 methyl 3-(4-fluorophenyl)-3-oxo-2-(triphenylphosphoranylidene)propanoate 
• 352-34-1 4-fluoro-1-iodobenzene 
• 1736-31-8 ethyl 3-(4-fluorophenyl)propiolate 
• 1743-00-6 4-fluoro-β,β-difluorostyrene 
• 109-72-8 n-butyllithium 

Downstream Products

• 80151-28-6 3-(4-fluoro-phenyl)-prop-2-yn-1-ol 
• 1621705-62-1 methyl 5-(benzyloxy)-2-(4-fluorophenyl)-6-(N-methylmethylsulfonamido)pyrazolo[1,5-a]pyridine-3-carboxylate 
• 313822-47-8 2-(4’-fluorophenyl)-1H-4-quinolone 
• 1407998-08-6 methyl 5-(4-fluorophenyl)-2-methyloxazole-4-carboxylate 
• 71845-10-8 dimethyl 3-(4-fluorophenyl)-1H-pyrrole-2,4-dicarboxylate 
• 1085712-43-1 methyl 2-(4-fluorophenyl)-6-methyl-pyrazolo[1,5-a]pyridine-3-carboxylate 
• 401815-71-2 C₁₆H₁₃FN₂O₂ 
• 1085712-41-9 C₁₅H₁₀F₂N₂O₂ 
• 1085712-40-8 C₁₅H₁₀F₂N₂O₂ 

Relevant articles and documents

Oxidation of aromatic compounds: XII. Regio- and stereoselective oxidative dimerization of alkyl 3-arylpropynoates in the system CF3CO 2H-CH2Cl2-PbO2

Regio- and stereoselective oxidative dimerization of alkyl 3-arylpropynoates in the system CF3CO2H-CH 2Cl2-PbO2 (1-30 h, 0-20°C) leads to dialkyl (E)-2,3-bis(arylcarbonyl)-2-butene-1,4-dioates with trans arrangement of the substituents at the double bond.

Synthesis and Characterization of Bidentate (P^N)Gold(III) Fluoride Complexes: Reactivity Platforms for Reductive Elimination Studies

A new family of cationic, bidentate (P^N)gold(III) fluoride complexes has been prepared and a detailed characterization of the gold-fluoride bond has been carried out. Our results correlate with the observed reactivity of the fluoro ligand, which undergoes facile exchange with both cyano and acetylene nucleophiles. The resulting (P^N)arylgold(III)C(sp) complexes have enabled the first study of reductive elimination on (P^N)gold(III) systems, which demonstrated that C(sp2)?C(sp) bond formation occurs at higher rates than those reported for analogous phosphine-based monodentate systems.

Oxidant- and additive-free simple synthesis of 1,1,2-triiodostyrenes by one-pot decaroboxylative iodination of propiolic acids

A metal- and oxidant-free facile synthesis of a range of 1,1,2-triiodostryrene derivatives has been developed which utilizes a simple decarboxylative triiodination of propiolic acids using molecular iodine and sodium acetate in a one-pot manner. Electron-