Technology Process of methyl 2,6-dichloro-4-aldehyde benzoate
There total 3 articles about methyl 2,6-dichloro-4-aldehyde benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2,6-dichloro-4-iodo-benzoic acid methyl ester;
With
isopropylmagnesium bromide;
In
tetrahydrofuran;
at -40 ℃;
for 0.5h;
N,N-dimethyl-formamide;
In
tetrahydrofuran;
at -40 - 20 ℃;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: N-Bromosuccinimide; diphenyl oxalate / dichloromethane / 40 h / Reflux
1.2: 0.75 h / 50 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 0 °C
With
N-Bromosuccinimide; diphenyl oxalate; potassium carbonate;
In
dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / 0.67 h / -78 °C
1.2: -78 - 20 °C
2.1: N-Bromosuccinimide; diphenyl oxalate / dichloromethane / 40 h / Reflux
2.2: 0.75 h / 50 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 0 °C
With
N-Bromosuccinimide; n-butyllithium; diphenyl oxalate; potassium carbonate;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
