5-((6R,7S)-7-Benzyloxy-6-methyl-1,4-dioxa-spiro[4.5]dec-6-yl)-pentan-2-one

Base Information

Chemical Name:5-((6R,7S)-7-Benzyloxy-6-methyl-1,4-dioxa-spiro[4.5]dec-6-yl)-pentan-2-one
CAS No.:77514-07-9
Molecular Formula:C₂₁H₃₀O₄
Molecular Weight:346.467
Hs Code.:

Synonyms:5-((6R,7S)-7-Benzyloxy-6-methyl-1,4-dioxa-spiro[4.5]dec-6-yl)-pentan-2-one

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Chemical Property of 5-((6R,7S)-7-Benzyloxy-6-methyl-1,4-dioxa-spiro[4.5]dec-6-yl)-pentan-2-one

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Technology Process of 5-((6R,7S)-7-Benzyloxy-6-methyl-1,4-dioxa-spiro[4.5]dec-6-yl)-pentan-2-one

There total 8 articles about 5-((6R,7S)-7-Benzyloxy-6-methyl-1,4-dioxa-spiro[4.5]dec-6-yl)-pentan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 77514-06-8
5-((6R,7S)-7-Benzyloxy-6-methyl-1,4-dioxa-spiro[4.5]dec-6-yl)-pentan-2-ol

: 77514-07-9
5-((6R,7S)-7-Benzyloxy-6-methyl-1,4-dioxa-spiro[4.5]dec-6-yl)-pentan-2-one

Guidance literature:: With pyridine; chromium(VI) oxide; In dichloromethane;
DOI:10.1016/S0040-4039(01)81818-9

Reference yield:

: 77514-01-3,126924-94-5
(4aS,5S)-5-Benzyloxy-4a-methyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one

: 77514-07-9
5-((6R,7S)-7-Benzyloxy-6-methyl-1,4-dioxa-spiro[4.5]dec-6-yl)-pentan-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 74 percent / H₂O₂, NaOH / methanol

2: 83 percent / p-TsNHNH₂ , AcOH / CH₂Cl₂

3: 95 percent / TsOH / benzene

4: 1.) 9-BBN 2.) 30percent H₂O₂ , 3N NaOH / 1.) THF

5: 97 percent / diethyl ether

6: 85 percent / CrO₃ , pyridine / CH₂Cl₂

With pyridine; chromium(VI) oxide; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide; toluene-4-sulfonic acid; acetic acid; toluene-4-sulfonic acid hydrazide; In methanol; diethyl ether; dichloromethane; benzene;
DOI:10.1016/S0040-4039(01)81818-9

Reference yield:

: 77514-03-5
(6R,7S)-7-Benzyloxy-6-but-3-ynyl-6-methyl-1,4-dioxa-spiro[4.5]decane

: 77514-07-9
5-((6R,7S)-7-Benzyloxy-6-methyl-1,4-dioxa-spiro[4.5]dec-6-yl)-pentan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 9-BBN 2.) 30percent H₂O₂ , 3N NaOH / 1.) THF

2: 97 percent / diethyl ether

3: 85 percent / CrO₃ , pyridine / CH₂Cl₂

With pyridine; chromium(VI) oxide; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide; In diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(01)81818-9