5-((6R,7S)-7-Benzyloxy-6-methyl-1,4-dioxa-spiro[4.5]dec-6-yl)-pentan-2-ol

Base Information

Chemical Name:5-((6R,7S)-7-Benzyloxy-6-methyl-1,4-dioxa-spiro[4.5]dec-6-yl)-pentan-2-ol
CAS No.:77514-06-8
Molecular Formula:C₂₁H₃₂O₄
Molecular Weight:348.483
Hs Code.:

Synonyms:5-((6R,7S)-7-Benzyloxy-6-methyl-1,4-dioxa-spiro[4.5]dec-6-yl)-pentan-2-ol

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Chemical Property of 5-((6R,7S)-7-Benzyloxy-6-methyl-1,4-dioxa-spiro[4.5]dec-6-yl)-pentan-2-ol

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Technology Process of 5-((6R,7S)-7-Benzyloxy-6-methyl-1,4-dioxa-spiro[4.5]dec-6-yl)-pentan-2-ol

There total 7 articles about 5-((6R,7S)-7-Benzyloxy-6-methyl-1,4-dioxa-spiro[4.5]dec-6-yl)-pentan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 917-54-4
methyllithium

: 77514-04-6
4-((6R,7S)-7-Benzyloxy-6-methyl-1,4-dioxa-spiro[4.5]dec-6-yl)-butyraldehyde

: 77514-06-8
5-((6R,7S)-7-Benzyloxy-6-methyl-1,4-dioxa-spiro[4.5]dec-6-yl)-pentan-2-ol

Guidance literature:: In diethyl ether;
DOI:10.1016/S0040-4039(01)81818-9

Reference yield:

: 77514-01-3,126924-94-5
(4aS,5S)-5-Benzyloxy-4a-methyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one

: 77514-06-8
5-((6R,7S)-7-Benzyloxy-6-methyl-1,4-dioxa-spiro[4.5]dec-6-yl)-pentan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 74 percent / H₂O₂, NaOH / methanol

2: 83 percent / p-TsNHNH₂ , AcOH / CH₂Cl₂

3: 95 percent / TsOH / benzene

4: 1.) 9-BBN 2.) 30percent H₂O₂ , 3N NaOH / 1.) THF

5: 97 percent / diethyl ether

With sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide; toluene-4-sulfonic acid; acetic acid; toluene-4-sulfonic acid hydrazide; In methanol; diethyl ether; dichloromethane; benzene;
DOI:10.1016/S0040-4039(01)81818-9

Reference yield:

: 77514-03-5
(6R,7S)-7-Benzyloxy-6-but-3-ynyl-6-methyl-1,4-dioxa-spiro[4.5]decane

: 77514-06-8
5-((6R,7S)-7-Benzyloxy-6-methyl-1,4-dioxa-spiro[4.5]dec-6-yl)-pentan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 9-BBN 2.) 30percent H₂O₂ , 3N NaOH / 1.) THF

2: 97 percent / diethyl ether

With sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide; In diethyl ether;
DOI:10.1016/S0040-4039(01)81818-9