(S)-2-Bromomethoxy-4-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-phenyl]-butyric acid methyl ester

Base Information

Chemical Name:(S)-2-Bromomethoxy-4-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-phenyl]-butyric acid methyl ester
CAS No.:1026868-52-9
Molecular Formula:C₂₇H₂₆BrNO₅
Molecular Weight:524.411
Hs Code.:

Synonyms:(S)-2-Bromomethoxy-4-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-phenyl]-butyric acid methyl ester

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Chemical Property of (S)-2-Bromomethoxy-4-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-phenyl]-butyric acid methyl ester

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Technology Process of (S)-2-Bromomethoxy-4-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-phenyl]-butyric acid methyl ester

There total 2 articles about (S)-2-Bromomethoxy-4-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-phenyl]-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 192204-24-3
(S)-4-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-phenyl]-2-methoxymethoxy-butyric acid methyl ester

: 1026868-52-9
(S)-2-Bromomethoxy-4-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-phenyl]-butyric acid methyl ester

Guidance literature:: With dimethylboron bromide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 ℃; for 0.333333h;
DOI:10.1021/jo962326p

Reference yield:

: 192204-23-2
(S)-4-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-phenyl]-2-hydroxy-butyric acid methyl ester

: 1026868-52-9
(S)-2-Bromomethoxy-4-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-phenyl]-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / DIPEA / tetrahydrofuran / 18 h / 0 - 20 °C

2: Me₂BBr, DIPEA / CH₂Cl₂ / 0.33 h / -78 °C

With dimethylboron bromide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo962326p

Reference yield:

: 1026868-52-9
(S)-2-Bromomethoxy-4-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-phenyl]-butyric acid methyl ester

: 192204-31-2
(S)-4-{2-[(S)-4-(2-Amino-phenyl)-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-butyrylamino]-phenyl}-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 450 mg / DIPEA / CH₂Cl₂ / 2 h / -78 °C

2: 58 percent / I₂, 3A MS / tetrahydrofuran / 48 h

3: 98 percent / piperidine / dimethylformamide / 0.33 h / Ambient temperature

4: 92 percent / Et₃N / methanol / 17 h

5: 94 percent / LiOH / tetrahydrofuran; methanol / 3 h / Ambient temperature

6: 70 percent / DIPEA, HATU / dimethylformamide / 24 h / Ambient temperature

7: 40 percent / TFA / CH₂Cl₂ / 0.25 h / Ambient temperature

With piperidine; lithium hydroxide; iodine; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo962326p