((R)-4-(6-(2-(methylamino)benzamido)hexanamido)cyclopent-1-en-1-yl)(butyl)phosphinic acid

Base Information

Chemical Name:((R)-4-(6-(2-(methylamino)benzamido)hexanamido)cyclopent-1-en-1-yl)(butyl)phosphinic acid
CAS No.:1425330-64-8
Molecular Formula:C₂₃H₃₆N₃O₄P
Molecular Weight:449.53
Hs Code.:

Synonyms:((R)-4-(6-(2-(methylamino)benzamido)hexanamido)cyclopent-1-en-1-yl)(butyl)phosphinic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ((R)-4-(6-(2-(methylamino)benzamido)hexanamido)cyclopent-1-en-1-yl)(butyl)phosphinic acid

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Technology Process of ((R)-4-(6-(2-(methylamino)benzamido)hexanamido)cyclopent-1-en-1-yl)(butyl)phosphinic acid

There total 6 articles about ((R)-4-(6-(2-(methylamino)benzamido)hexanamido)cyclopent-1-en-1-yl)(butyl)phosphinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

((R)-4-(6-aminohexanamido)cyclopent-1-en-1-yl)(butyl)phosphinic acid: 1425330-48-8
((R)-4-(6-aminohexanamido)cyclopent-1-en-1-yl)(butyl)phosphinic acid

: 64156-72-5
2-methylaminobenzoic acid 2,5-dioxopyrrolidin-1-yl ester

: 1425330-64-8
((R)-4-(6-(2-(methylamino)benzamido)hexanamido)cyclopent-1-en-1-yl)(butyl)phosphinic acid

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; 1,2-dimethoxyethane; water; at 20 ℃; for 16h;
DOI:10.1021/ml300476v

Reference yield:

: 6404-29-1
6-(tert-butoxycarbonylamino)hexanoic acid

: 1425330-64-8
((R)-4-(6-(2-(methylamino)benzamido)hexanamido)cyclopent-1-en-1-yl)(butyl)phosphinic acid

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 0 - 20 °C

2: sodium hydrogencarbonate / water; 1,2-dimethoxyethane; tetrahydrofuran / 16 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 20 °C

4: sodium hydrogencarbonate / water; 1,2-dimethoxyethane; tetrahydrofuran / 16 h / 20 °C

With dmap; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;
DOI:10.1021/ml300476v

Reference yield:

: 51513-80-5
N-Boc-6-aminohexanoic acid N-hydroxysuccinimide ester

: 1425330-64-8
((R)-4-(6-(2-(methylamino)benzamido)hexanamido)cyclopent-1-en-1-yl)(butyl)phosphinic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / water; 1,2-dimethoxyethane; tetrahydrofuran / 16 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 20 °C

3: sodium hydrogencarbonate / water; 1,2-dimethoxyethane; tetrahydrofuran / 16 h / 20 °C

With sodium hydrogencarbonate; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;
DOI:10.1021/ml300476v