Succinimidyl N-methylanthranilate

Base Information

• Chemical Name: Succinimidyl N-methylanthranilate
• CAS No.: 64156-72-5
• Molecular Formula: C12H12 N2 O4
• Molecular Weight: 248.238
• Hs Code.: 2925190090
• DSSTox Substance ID: DTXSID90376362
• Nikkaji Number: J1.234.116D
• Wikidata: Q82165304
• Mol file: 64156-72-5.mol

Synonyms:Succinimidyl N-methylanthranilate;64156-72-5;2,5-dioxopyrrolidin-1-yl 2-(methylamino)benzoate;(2,5-dioxopyrrolidin-1-yl) 2-(methylamino)benzoate;SCHEMBL4352600;DTXSID90376362;FT-0764917;2-(Methylamino)benzoic acid succinimidyl ester;2,5-dioxopyrrolidin-1-yl2-(methylamino)benzoate;Benzoic acid,2-(methylamino)-,2,5-dioxo-1-pyrrolidinyl ester

Chemical Property of Succinimidyl N-methylanthranilate

Chemical Property:

• Vapor Pressure: 3.66E-07mmHg at 25°C
• Boiling Point: 417°C at 760 mmHg
• Flash Point: 206°C
• PSA: 75.71000
• Density: 1.37g/cm³
• LogP: 0.96000
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 248.07970687
• Heavy Atom Count: 18
• Complexity: 353

Purity/Quality:

98%Min ^*data from raw suppliers

SUCCINIMIDYL-N-METHYL ANTHRANILATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC1=CC=CC=C1C(=O)ON2C(=O)CCC2=O

Technology Process of Succinimidyl N-methylanthranilate

There total 1 articles about Succinimidyl N-methylanthranilate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + N-Methylanthranilic acid (119-68-6) → 2-methylaminobenzoic acid 2,5-dioxopyrrolidin-1-yl ester (64156-72-5)

Guidance literature:

With dicyclohexyl-carbodiimide; In 1,2-dimethoxyethane; at 20 ℃; for 48h;

DOI:10.1248/cpb.48.211

Reference yield: 84.0%

((S)-4-(7-aminoheptanamido)cyclopent-1-en-1-yl)(butyl)phosphinic acid (1425330-56-8) + 2-methylaminobenzoic acid 2,5-dioxopyrrolidin-1-yl ester (64156-72-5) → ((S)-4-(7-(2-(methylamino)benzamido)heptanamido)cyclopent-1-en-1-yl)(butyl)phosphinic acid (1425330-72-8)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; 1,2-dimethoxyethane; water; at 20 ℃; for 16h;

DOI:10.1021/ml300476v

Reference yield: 83.0%

((S)-4-(5-aminopentanamido)cyclopent-1-en-1-yl)(butyl)phosphinic acid (1425330-46-6) + 2-methylaminobenzoic acid 2,5-dioxopyrrolidin-1-yl ester (64156-72-5) → ((S)-4-(5-(2-(methylamino)benzamido)pentanamido)cyclopent-1-en-1-yl)(butyl)phosphinic acid (1425330-62-6)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; 1,2-dimethoxyethane; water; at 20 ℃; for 16h;

DOI:10.1021/ml300476v

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

N-Methylanthranilic acid

Downstream raw materials:

1,4-dihydro-1-methyl-4-oxo-2-phenylquinoline-3-carboxylic acid ethyl ester

((S)-4-(2-(2-(methylamino)benzamido)acetamido)cyclopent-1-en-1-yl)(butyl)phosphinic acid

((S)-4-(4-(2-(methylamino)benzamido)butanamido)cyclopent-1-en-1-yl)(butyl)phosphinic acid

((S)-4-(5-(2-(methylamino)benzamido)pentanamido)cyclopent-1-en-1-yl)(butyl)phosphinic acid

Refernces

• 1、 Gavande, Navnath,Kim, Hye-Lim,Doddareddy, Munikumar R.,Johnston, Graham A. R.,Chebib, Mary,Hanrahan, Jane R.. "Design, synthesis, and pharmacological evaluation of fluorescent and biotinylated antagonists of ρ1 GABAC receptors". supporting information. p. 402 - 407. Retrieved 2013/06/05.