(R)-3-benzyloxy-3-((R)-2,2-dimethyl[1,3]dioxolan-4-yl)-2,2-dimethylpropionic acid methyl ester

Base Information

Chemical Name:(R)-3-benzyloxy-3-((R)-2,2-dimethyl[1,3]dioxolan-4-yl)-2,2-dimethylpropionic acid methyl ester
CAS No.:895532-68-0
Molecular Formula:C₁₈H₂₆O₅
Molecular Weight:322.401
Hs Code.:

Synonyms:(R)-3-benzyloxy-3-((R)-2,2-dimethyl[1,3]dioxolan-4-yl)-2,2-dimethylpropionic acid methyl ester

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Chemical Property of (R)-3-benzyloxy-3-((R)-2,2-dimethyl[1,3]dioxolan-4-yl)-2,2-dimethylpropionic acid methyl ester

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Technology Process of (R)-3-benzyloxy-3-((R)-2,2-dimethyl[1,3]dioxolan-4-yl)-2,2-dimethylpropionic acid methyl ester

There total 6 articles about (R)-3-benzyloxy-3-((R)-2,2-dimethyl[1,3]dioxolan-4-yl)-2,2-dimethylpropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 895532-48-6
(R)-3-((R)-2,2-dimethyl[1,3]dioxolan-4-yl)-3-hydroxy-2,2-dimethylpropionic acid methyl ester

: 100-39-0
benzyl bromide

: 895532-68-0
(R)-3-benzyloxy-3-((R)-2,2-dimethyl[1,3]dioxolan-4-yl)-2,2-dimethylpropionic acid methyl ester

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1021/ol060827j

Reference yield:

: 3-((R)-2,2-dimethyl[1,3]dioxolan-4-yl)-3-hydroxy-2,2-dimethylpropionic acid methyl ester

: 895532-68-0
(R)-3-benzyloxy-3-((R)-2,2-dimethyl[1,3]dioxolan-4-yl)-2,2-dimethylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / N-methylmorpholine N-oxide monohydrate; tetrapropylammonium perruthenate; molecular sieves 4 Angstroem / acetonitrile; CH₂Cl₂ / 0.5 h

2: zinc borohydride / diethyl ether / 1 h / -100 - -40 °C

3: 92 percent / sodium hydride / dimethylformamide / 0 - 20 °C

With tetrapropylammonium perruthennate; 4 A molecular sieve; zinc borohydride; sodium hydride; 4-methylmorpholine N-oxide; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo070861r

Reference yield:

: 895532-67-9
(R)-methyl 3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyl-3-oxopropanoate

: 895532-68-0
(R)-3-benzyloxy-3-((R)-2,2-dimethyl[1,3]dioxolan-4-yl)-2,2-dimethylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: zinc borohydride / diethyl ether / 1 h / -100 - -40 °C

2: 92 percent / sodium hydride / dimethylformamide / 0 - 20 °C

With zinc borohydride; sodium hydride; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jo070861r