(+)-N₁,N₄-di-(tert-butyloxycarbonyl)-N-[3-[(1H-imidazol-1-yl)-methyl]phenyl]-(2R)-piperazinecarboxamide

Base Information

• Chemical Name: (+)-N₁,N₄-di-(tert-butyloxycarbonyl)-N-[3-[(1H-imidazol-1-yl)-methyl]phenyl]-(2R)-piperazinecarboxamide
• CAS No.: 892393-40-7
• Molecular Formula: C₂₅H₃₅N₅O₅
• Molecular Weight: 485.583

Synonyms:(+)-N₁,N₄-di-(tert-butyloxycarbonyl)-N-[3-[(1H-imidazol-1-yl)-methyl]phenyl]-(2R)-piperazinecarboxamide

Chemical Property of (+)-N₁,N₄-di-(tert-butyloxycarbonyl)-N-[3-[(1H-imidazol-1-yl)-methyl]phenyl]-(2R)-piperazinecarboxamide

Chemical Property:

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Technology Process of (+)-N₁,N₄-di-(tert-butyloxycarbonyl)-N-[3-[(1H-imidazol-1-yl)-methyl]phenyl]-(2R)-piperazinecarboxamide

There total 3 articles about (+)-N₁,N₄-di-(tert-butyloxycarbonyl)-N-[3-[(1H-imidazol-1-yl)-methyl]phenyl]-(2R)-piperazinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

(R)-piperazine-1,2,4-tricarboxylic acid 1,4-di-tert-butyl ester (173774-48-6) + 3-(1H-imidazol-1-ylmethyl)benzenamine (120107-85-9) → (+)-N1,N4-di-(tert-butyloxycarbonyl)-N-[3-[(1H-imidazol-1-yl)-methyl]phenyl]-(2R)-piperazinecarboxamide (892393-40-7)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 25 ℃; for 239 - 329h; Product distribution / selectivity;

Reference yield: 13.0%

(+)-N-[3-[(1H-imidazol-1-yl)methyl]phenyl]-(2R)-piperazine-carboxamide (892393-39-4) + di-tert-butyl dicarbonate (24424-99-5) → (-)-N1-(tert-butyloxycarbonyl)-N-[3-[(1H-imidazol-1-yl)methyl]phenyl]-(3R)-piperazinecarboxamide (892393-56-5) + (+)-N1,N4-di-(tert-butyloxycarbonyl)-N-[3-[(1H-imidazol-1-yl)-methyl]phenyl]-(2R)-piperazinecarboxamide (892393-40-7)

Guidance literature:

In tetrahydrofuran; water; at 25 ℃; for 16h;

Reference yield:

C15H25ClN2O5 + 3-(1H-imidazol-1-ylmethyl)benzenamine (120107-85-9) → (+)-N1,N4-di-(tert-butyloxycarbonyl)-N-[3-[(1H-imidazol-1-yl)-methyl]phenyl]-(2R)-piperazinecarboxamide (892393-40-7)

Guidance literature:

With triethylamine; In dichloromethane; at -78 ℃; for 1.5h; Product distribution / selectivity;

upstream raw materials:

(R)-piperazine-1,2,4-tricarboxylic acid 1,4-di-tert-butyl ester

3-(1H-imidazol-1-ylmethyl)benzenamine

(+)-N-[3-[(1H-imidazol-1-yl)methyl]phenyl]-(2R)-piperazine-carboxamide

di-tert-butyl dicarbonate

Downstream raw materials:

(-)-N₁,N₄-di-(tert-butyloxycarbonyl)-N-(benzyl)-N-[3-[(1H-imidazol-1-yl)methyl]phenyl]-(2R)-piperazinecarboxamide

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