120107-85-9

Usage

Uses

Used in Pharmaceutical Industry:
3-(1H-IMIDAZOL-1-YLMETHYL)ANILINE is used as a selective aldosterone synthase inhibitor for the treatment of conditions related to aldosterone overproduction, such as hypertension and heart failure. It works by inhibiting the enzyme aldosterone synthase, which is responsible for the synthesis of aldosterone, a hormone that regulates blood pressure and electrolyte balance.
Used in Antibacterial and Antifungal Applications:
3-(1H-IMIDAZOL-1-YLMETHYL)ANILINE is also being researched for its potential as an antibacterial and antifungal agent. Its benzenamine derivative structure may contribute to its effectiveness in combating bacterial and fungal infections, making it a promising candidate for the development of new drugs in the field of infectious diseases.

InChI:InChI=1/C10H11N3/c11-10-3-1-2-9(6-10)7-13-5-4-12-8-13/h1-6,8H,7,11H2

Upstream product

• 56643-75-5 1-(3-nitro-benzyl)-1H-imidazole 
• 5587-42-8 imidazolyl sodium 
• 3958-57-4 1-bromomethyl-3-nitrobenzene 
• 99-08-1 1-methyl-3-nitrobenzene 
• 892393-24-7 1-(1H-imidazol-1-yl)-1-[3-[(tert-butoxycarbonyl)amino]phenyl]-methane 

Downstream Products

• 120108-23-8 N-(3-Imidazol-1-ylmethyl-phenyl)-2,4-dinitro-benzamide 
• 120108-12-5 4-Chloro-N-(3-imidazol-1-ylmethyl-phenyl)-2-nitro-benzamide 
• 120123-73-1 (3-Imidazol-1-ylmethyl-phenyl)-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-amine 
• 120107-89-3 N-(4-{[(E)-3-Imidazol-1-ylmethyl-phenylimino]-methyl}-phenyl)-acetamide 
• 120107-87-1 (3-Imidazol-1-ylmethyl-phenyl)-[1-(3,4,5-trimethoxy-phenyl)-meth-(E)-ylidene]-amine 
• 120108-22-7 N-(3-Imidazol-1-ylmethyl-phenyl)-3,4,5-trimethoxy-benzamide 
• 120108-21-6 N-(3-Imidazol-1-ylmethyl-phenyl)-benzamide 
• 120107-90-6 [1-(2,4-Dichloro-phenyl)-meth-(E)-ylidene]-(3-imidazol-1-ylmethyl-phenyl)-amine 
• 120108-17-0 4-Chloro-N-(3-imidazol-1-ylmethyl-phenyl)-benzamide 
• 120107-88-2 C₁₉H₂₀N₄ 
• 120107-93-9 (3-Imidazol-1-ylmethyl-phenyl)-[1-(2-nitro-phenyl)-meth-(E)-ylidene]-amine 
• 120108-13-6 N-(3-Imidazol-1-ylmethyl-phenyl)-3-nitro-benzamide 
• 892393-40-7 (+)-N₁,N₄-di-(tert-butyloxycarbonyl)-N-[3-[(1H-imidazol-1-yl)-methyl]phenyl]-(2R)-piperazinecarboxamide 
• 892393-38-3 (-)-N₁,N₄-di-(tert-butyloxycarbonyl)-N-[3-[(1H-imidazol-1-yl)-methyl]phenyl]-(2S)-piperazinecarboxamide 

Relevant academic research and scientific papers

Reversible photoresponsive activity of a carbonic anhydrase mimic

The carbonic anhydrase (CA) enzyme reversibly transforms carbon dioxide and water to a carbonate ion and a proton. Photoresponsive enzyme mimics, where the CA-activity can be turned on and off reversibly with light, have not been reported so far. We have designed an active site mimic that offers reversible control of the catalytic activity using light. Moreover, in the presence of a cationic polymer, we have demonstrated that the CA-activity was further enhanced by stabilizing the transition state with the cis-form of the enzyme mimic which can catalyze the hydration of gaseous CO2.

Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. identification of a suitable "back-up" compound for N-tert-butyl isoquine

On the basis of a mechanistic understanding of the toxicity of the 4-aminoquinoline amodiaquine (1b), three series of amodiaquine analogues have been prepared where the 4-aminophenol "metabolic alert" has been modified by replacement of the 4'-hydroxy gro

FARNESYL PROTEIN TRANSFERASE INHIBITORS AND METHODS FOR TREATING PROLIFERATIVE DISEASES

Disclosed are compounds of the Formula: (1.0) wherein the substituents are as defined herein. Also disclosed are uses of the compounds of formula 1.0 for the manufacture of a medicament for treating cancer and for inhibiting farnesyl protein transferase.

2-Pyridinecarbothioamides and pharmaceutical compositions comprising the same

There are provided gastric antiulcer and cytoprotective substituted N-phenyl-2-pyridinecarbothioamides. The process for their production and formulation is disclosed.

Research on anti-bacterial and anti-fungal agents II. Synthesis and anti-fungal activity of new (1H-imidazol-1-ylmethyl)benzenamine derivatives

The synthesis and in vivo and in vitro anti-fungal activities of new (1H-imidazol-1-ylmethyl)benzenamine derivatives are reported.Anti-microbial data in comparison with miconazole show that many compounds exhibit an interesting anti-mycotic activity.Keywo