trifluoromethanesulfonic acid 1-benzyl-2,5-dihydro-1H-pyrrol-3-yl ester

Base Information

• Chemical Name: trifluoromethanesulfonic acid 1-benzyl-2,5-dihydro-1H-pyrrol-3-yl ester
• CAS No.: 284465-88-9
• Molecular Formula: C₁₂H₁₂F₃NO₃S
• Molecular Weight: 307.293
• Mol file: 284465-88-9.mol

Synonyms:trifluoromethanesulfonic acid 1-benzyl-2,5-dihydro-1H-pyrrol-3-yl ester

Chemical Property of trifluoromethanesulfonic acid 1-benzyl-2,5-dihydro-1H-pyrrol-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of trifluoromethanesulfonic acid 1-benzyl-2,5-dihydro-1H-pyrrol-3-yl ester

There total 2 articles about trifluoromethanesulfonic acid 1-benzyl-2,5-dihydro-1H-pyrrol-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

N,N-phenylbistrifluoromethane-sulfonimide (37595-74-7) + N-benzyl-3-pyrrolidinone (775-16-6) → trifluoromethanesulfonic acid 1-benzyl-2,5-dihydro-1H-pyrrol-3-yl ester (284465-88-9)

Guidance literature:

N-benzyl-3-pyrrolidinone; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

N,N-phenylbistrifluoromethane-sulfonimide; In tetrahydrofuran; at -78 - 0 ℃;

DOI:10.1016/S0040-4039(00)00392-0

Reference yield:

→ trifluoromethanesulfonic acid 1-benzyl-2,5-dihydro-1H-pyrrol-3-yl ester (284465-88-9)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

In tetrahydrofuran; at -78 ℃; for 2h;

Reference yield: 74.0%

1-Naphthylboronic acid (13922-41-3) + trifluoromethanesulfonic acid 1-benzyl-2,5-dihydro-1H-pyrrol-3-yl ester (284465-88-9) → 1-benzyl-3-naphthalen-1-yl-1H-pyrrole

Guidance literature:

With potassium acetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 100 ℃;

DOI:10.1016/S0040-4039(00)00392-0

upstream raw materials:

N,N-phenylbistrifluoromethane-sulfonimide

N-benzyl-3-pyrrolidinone