[(R,R)-2-(2-iodophenyl)-5-phenyl-4,5-dihydrooxazol-4-yl]methanol

Base Information

• Chemical Name: [(R,R)-2-(2-iodophenyl)-5-phenyl-4,5-dihydrooxazol-4-yl]methanol
• CAS No.: 872052-32-9
• Molecular Formula: C₁₆H₁₄INO₂
• Molecular Weight: 379.197
• Mol file: 872052-32-9.mol

Synonyms:[(R,R)-2-(2-iodophenyl)-5-phenyl-4,5-dihydrooxazol-4-yl]methanol

Chemical Property of [(R,R)-2-(2-iodophenyl)-5-phenyl-4,5-dihydrooxazol-4-yl]methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of [(R,R)-2-(2-iodophenyl)-5-phenyl-4,5-dihydrooxazol-4-yl]methanol

There total 1 articles about [(R,R)-2-(2-iodophenyl)-5-phenyl-4,5-dihydrooxazol-4-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

2-iodobenzonitrile (4387-36-4) + (1R,2R)-2-amino-1-phenylpropane-1,3-diol (46032-98-8) → [(R,R)-2-(2-iodophenyl)-5-phenyl-4,5-dihydrooxazol-4-yl]methanol (872052-32-9)

Guidance literature:

With cadmium(II) acetate; In chlorobenzene; for 16h; Heating;

DOI:10.1021/jo051610q

Reference yield: 90.0%

[(R,R)-2-(2-iodophenyl)-5-phenyl-4,5-dihydrooxazol-4-yl]methanol (872052-32-9) + dimethyl sulfate (77-78-1) → (R,R)-2-(2-iodophenyl)-4-methoxymethyl-5-phenyl-4,5-dihydrooxazole (872052-34-1)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1021/jo051610q

Reference yield: 78.0%

[(R,R)-2-(2-iodophenyl)-5-phenyl-4,5-dihydrooxazol-4-yl]methanol (872052-32-9) + diphenylphosphane (829-85-6) → [(R,R)-2-(2-diphenylphosphinophenyl)-5-phenyl-4,5-dihydrooxazol-4-yl]methanol

Guidance literature:

With palladium diacetate; triethylamine; In acetonitrile; for 4h; Heating;

DOI:10.1021/jo051610q

upstream raw materials:

2-iodobenzonitrile

(1R,2R)-2-amino-1-phenylpropane-1,3-diol

Downstream raw materials:

(R,R)-2-(2-iodophenyl)-4-methoxymethyl-5-phenyl-4,5-dihydrooxazole