H-Phe-ΔLeu-OBzl*HCl

Base Information

• Chemical Name: H-Phe-ΔLeu-OBzl*HCl
• CAS No.: 86960-62-5
• Molecular Formula: C₂₂H₂₆N₂O₃*ClH
• Molecular Weight: 402.921
• Mol file: 86960-62-5.mol

Synonyms:H-Phe-ΔLeu-OBzl*HCl

Chemical Property of H-Phe-ΔLeu-OBzl*HCl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of H-Phe-ΔLeu-OBzl*HCl

There total 4 articles about H-Phe-ΔLeu-OBzl*HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

t-butoxycarbonyl-L-phenylalanyl-(Z)-α,β-dehydroleucine benzyl ester (87067-90-1) → H-Phe-ΔLeu-OBzl*HCl (86960-62-5)

Guidance literature:

With hydrogenchloride; In ethyl acetate; for 2h; Ambient temperature;

Reference yield:

L-Leucine benzyl ester (1738-69-8) → H-Phe-ΔLeu-OBzl*HCl (86960-62-5)

Guidance literature:

Multi-step reaction with 4 steps

1: t-butyl hypochlorite / diethyl ether / 0.5 h / 0 °C

2: 1.) DBU, 2.) HCl / 1.) ether, room temperature, 30 min., 2.) EtOAC, -70 deg C

3: 47 percent / Et₃N, HOBt, EDC*HCl / CHCl₃ / 1.) 0 deg C, 2 h, 2.) room temperature

4: 100 percent / 2.8M HCl / ethyl acetate / 2 h / Ambient temperature

With hydrogenchloride; tert-butylhypochlorite; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In diethyl ether; chloroform; ethyl acetate;

Reference yield:

N-chloroleucine benzyl ester (86960-60-3) → H-Phe-ΔLeu-OBzl*HCl (86960-62-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) DBU, 2.) HCl / 1.) ether, room temperature, 30 min., 2.) EtOAC, -70 deg C

2: 47 percent / Et₃N, HOBt, EDC*HCl / CHCl₃ / 1.) 0 deg C, 2 h, 2.) room temperature

3: 100 percent / 2.8M HCl / ethyl acetate / 2 h / Ambient temperature

With hydrogenchloride; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In chloroform; ethyl acetate;

upstream raw materials:

t-butoxycarbonyl-L-phenylalanyl-(Z)-α,β-dehydroleucine benzyl ester

L-Leucine benzyl ester

N-chloroleucine benzyl ester

H-ΔLeu-OBzl*HCl

Downstream raw materials:

t-butoxycarbonyl-glycyl-glycyl-L-phenylalanyl-(Z)-α,β-dehydroleucine benzyl ester

t-butoxycarbonyl-D-alanyl-glycyl-L-phenylalanyl-(Z)-α,β-dehydroleucine benzyl ester

L-tyrocyl-glycyl-glycyl-L-phenylalanyl-(Z)-α,β-dehydroleucine

L-tyrocyl-D-alanyl-glycyl-L-phenylalanyl-(Z)-α,β-dehydroleucine