15-(2-phenylethyn-1-yl)-2,3,5,6,8,9,11,12-octahydro-1,4,7,10,13-pentaoxabenzocyclopentadecine

Base Information

• Chemical Name: 15-(2-phenylethyn-1-yl)-2,3,5,6,8,9,11,12-octahydro-1,4,7,10,13-pentaoxabenzocyclopentadecine
• CAS No.: 70127-38-7
• Molecular Formula: C₂₂H₂₄O₅
• Molecular Weight: 368.43
• Mol file: 70127-38-7.mol

Synonyms:15-(2-phenylethyn-1-yl)-2,3,5,6,8,9,11,12-octahydro-1,4,7,10,13-pentaoxabenzocyclopentadecine

Chemical Property of 15-(2-phenylethyn-1-yl)-2,3,5,6,8,9,11,12-octahydro-1,4,7,10,13-pentaoxabenzocyclopentadecine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 15-(2-phenylethyn-1-yl)-2,3,5,6,8,9,11,12-octahydro-1,4,7,10,13-pentaoxabenzocyclopentadecine

There total 3 articles about 15-(2-phenylethyn-1-yl)-2,3,5,6,8,9,11,12-octahydro-1,4,7,10,13-pentaoxabenzocyclopentadecine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

iodobenzene (591-50-4) + 15-ethynyl-2,3,5,6,8,9,11,12-octahydro-1,4,7,10,13-pentaoxabenzocyclopentadecene (92710-94-6) → 15-(2-phenylethyn-1-yl)-2,3,5,6,8,9,11,12-octahydro-1,4,7,10,13-pentaoxabenzocyclopentadecine (70127-38-7)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In benzene; at 70 - 75 ℃; for 2h;

DOI:10.1023/A:1021311824043

Reference yield: 72.0%

2-iodo-6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxabenzocyclopentadecene (69591-40-8) + phenylacetylene (536-74-3) → 15-(2-phenylethyn-1-yl)-2,3,5,6,8,9,11,12-octahydro-1,4,7,10,13-pentaoxabenzocyclopentadecine (70127-38-7)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In benzene; at 70 - 75 ℃; for 2h;

DOI:10.1023/A:1021311824043

Reference yield:

→ 15-(2-phenylethyn-1-yl)-2,3,5,6,8,9,11,12-octahydro-1,4,7,10,13-pentaoxabenzocyclopentadecine (70127-38-7)

Guidance literature:

Aus 15-Iodbenzo-15-crown-5 u. Kupferphenylacetylid;

DOI:10.1016/S0022-328X(00)91998-3

upstream raw materials:

iodobenzene

15-ethynyl-2,3,5,6,8,9,11,12-octahydro-1,4,7,10,13-pentaoxabenzocyclopentadecene

2-iodo-6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxabenzocyclopentadecene

phenylacetylene