1-Bromo-4-chloro-5-fluoro-2-methylbenzene

Base Information

• Chemical Name: 1-Bromo-4-chloro-5-fluoro-2-methylbenzene
• CAS No.: 1067882-53-4
• Molecular Formula: C₇H₅BrClF
• Molecular Weight: 223.472
• Hs Code.: 2903998090
• Mol file: 1067882-53-4.mol

Synonyms:1-bromo-4-chloro-5-fluoro-2-methyl-benzene

Chemical Property of 1-Bromo-4-chloro-5-fluoro-2-methylbenzene

Chemical Property:

• Boiling Point: 221.4±35.0 °C(Predicted)
• Density: 1.618±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromo-5-chloro-4-fluorotoluene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Bromo-4-chloro-5-fluoro-2-methylbenzene

There total 2 articles about 1-Bromo-4-chloro-5-fluoro-2-methylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-2-chloro-4-methyl-phenylamine (1067882-54-5) → 1-bromo-4-chloro-5-fluoro-2-methyl-benzene (1067882-53-4)

Guidance literature:

5-bromo-2-chloro-4-methyl-phenylamine; With hydrogenchloride; In water; at 80 ℃;

With sodium nitrite; In water; at 0 ℃; for 1h;

With hydrogen fluoride; boric acid; In water; for 0.5h;

Reference yield:

1-bromo-4-chloro-2-methyl-5-nitrobenzene (10289-13-1) → 1-bromo-4-chloro-5-fluoro-2-methyl-benzene (1067882-53-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: formamidine acetic acid; hydrogen / nickel / methanol; water / 1 h / 80 °C / 9000.9 Torr

2.1: hydrogenchloride / water / 80 °C

2.2: 1 h / 0 °C

2.3: 0.5 h

With hydrogenchloride; formamidine acetic acid; hydrogen; nickel; In methanol; water;

Reference yield:

1-bromo-4-chloro-5-fluoro-2-methyl-benzene (1067882-53-4) → 1-bromo-2-bromomethyl-4-chloro-5-fluoro-benzene (1067882-52-3)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 15h; Heating / reflux;

upstream raw materials:

5-bromo-2-chloro-4-methyl-phenylamine

1-bromo-4-chloro-2-methyl-5-nitrobenzene

Downstream raw materials:

1-bromo-2-bromomethyl-4-chloro-5-fluoro-benzene

(2-bromo-5-chloro-4-fluoro-phenyl)-methanol

(2-bromo-5-chloro-4-fluoro-phenyl)-acetonitrile

C₉H₇BrClFO₂

Refernces