Technology Process of 2-benzyloxymethyl-6-(3,3-dimethoxypropyl)-1-azaspiro[4.5]decane
There total 9 articles about 2-benzyloxymethyl-6-(3,3-dimethoxypropyl)-1-azaspiro[4.5]decane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydride;
In
tetrahydrofuran;
at 20 ℃;
for 72h;
DOI:10.1021/jo0201070
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 81 percent / NaNO2; HCl; CuCl / 4 Angstroem molecular sieves / methanol / 1.5 h / 18 °C
2.1: 76 percent / BF3*Et2O; CuBr2*Me2S / diethyl ether / 4 h / -78 - 20 °C
3.1: BF3*2AcOH / CH2Cl2 / 0.25 h / 20 °C
3.2: 95 percent / NaHCO3; aq. H2O2 / methanol; tetrahydrofuran / Heating
4.1: H2; Rh(CO)2acac; P(OPh)3 / tetrahydrofuran / 6 h / 60 °C / 3040.2 Torr
5.1: 77 mg / HCl / methanol / 0.17 h / 20 °C
6.1: 99 percent / LiOH*H2O / ethanol / 168 h / Heating
7.1: 75 percent / NaH / tetrahydrofuran / 72 h / 20 °C
With
triphenyl phosphite; hydrogenchloride; acetylacetonatodicarbonylrhodium(l); lithium hydroxide; copper bromide dimethyl sulfide complex; boron trifluoride diethyl etherate; hydrogen; boron trifluoride diacetate; sodium hydride; copper(l) chloride; sodium nitrite;
4 A molecular sieve;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane;
3.2: Tamao oxidation;
DOI:10.1021/jo0201070
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 95 percent / NaBH4; Cu(acac)2 / ethanol / 3 h / 20 °C
2.1: 81 percent / NaNO2; HCl; CuCl / 4 Angstroem molecular sieves / methanol / 1.5 h / 18 °C
3.1: 76 percent / BF3*Et2O; CuBr2*Me2S / diethyl ether / 4 h / -78 - 20 °C
4.1: BF3*2AcOH / CH2Cl2 / 0.25 h / 20 °C
4.2: 95 percent / NaHCO3; aq. H2O2 / methanol; tetrahydrofuran / Heating
5.1: H2; Rh(CO)2acac; P(OPh)3 / tetrahydrofuran / 6 h / 60 °C / 3040.2 Torr
6.1: 77 mg / HCl / methanol / 0.17 h / 20 °C
7.1: 99 percent / LiOH*H2O / ethanol / 168 h / Heating
8.1: 75 percent / NaH / tetrahydrofuran / 72 h / 20 °C
With
triphenyl phosphite; hydrogenchloride; copper acetylacetonate; acetylacetonatodicarbonylrhodium(l); lithium hydroxide; sodium tetrahydroborate; copper bromide dimethyl sulfide complex; boron trifluoride diethyl etherate; hydrogen; boron trifluoride diacetate; sodium hydride; copper(l) chloride; sodium nitrite;
4 A molecular sieve;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane;
4.2: Tamao oxidation;
DOI:10.1021/jo0201070
